http://www.livescience.com/culture/brain-3d-map-copy-cat-101115.html Chinese team's brain imaging device has come under question from developers of a U.S. device who say it's a near duplicate of theirs, LiveScience has learned. An article on the Chinese device was published in the prestigious journal Science, and the U.S. researchers are preparing a formal letter to the journal in response. According to the report appearing in the Nov. 4 online edition of Science, the Chinese imaging device used a diamond knife to shave ribbons off a centimeter-size mouse brain and imaged the slices during the process. That allowed the Chinese team to create a 3-D map of the brain that revealed details as small as the axons and dendrites — the circuitry that transmits signals between brain cells — as a step in the race to map the connections in the brain. LiveScience contacted Yoonsuck Choe, director of the Brain Networks Laboratory at Texas A&M University, for comment on the Chinese device the day the paper was published, and the inquiry by the website immediately set off alarms. Choe's lab, which had developed its own knife-edge scanning microscope, or KESM, said today (Nov. 15) it will not officially comment in detail because it is preparing an official "Letter to Science" submission to formally alert the editors of the journal. The U.S. researchers have already contacted the journal with their concerns, and a Science representative told LiveScience that the matter is being taken seriously. Choe said he suspects the Chinese researchers copied the KESM design to create their own version of the brain imaging device. Due to LiveScience's early involvement in the controversy, the website has been able to reconstruct some background on how the U.S. brain imaging device could have been copied. How it went down Choe's lab started the development of its KESM almost a decade ago. The main architect behind the instrument was Bruce McCormick (1928-2007), a computer scientist at Texas A&M University. The Chinese group in question hails from the Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics– Huazhong University of Science and Technology, in China. Choe possesses an e-mail that shows the same Chinese lab previously asking the main engineering contractor for Choe's lab, Micro Star Technologies, for a custom-made diamond knife. The knife forms a key part of the KESM, along with commercially available components such as the camera. Micro Star Technologies refused the Chinese request. Now made in China Despite Micro Star's refusal, Choe said he believes the Chinese team may have gotten enough information about KESM from detailed online technical reports and a Journal of Microscopy article to manufacture a nearly exact replica. The Chinese researchers, led by Qingming Luo, named their device the Micro- Optical Sectioning Tomography, or MOST. They did not respond to an e-mail request for an interview from LiveScience at the time they announced the device. Initial e-mail requests for comment by the Chinese team were not returned. Choe said technical specs and details for MOST make the device an almost perfect replica of KESM. The Chinese researchers gave only passing mention to the U.S. team in the Science article. Suspicions first arose when LiveScience contacted Sebastian Seung, a computational neuroscientist at MIT. He leads a collaborative effort to speed up the mapping of the brain's wiring diagrams, known as connectomes. "I just looked at it briefly, but it doesn't seem novel," Seung said in an e -mail on the morning of Nov. 4. "Isn't it equivalent to this?" "This" referred to the KESM developed by Choe's lab. Seung then suggested contacting Choe. A tale of two labs Choe and his colleagues e-mailed their concerns to Science on the night of Nov. 4, along with the technical information and publication references to support those concerns. The journal confirmed to LiveScience that it had received the concerns of Choe's lab and that the Science editorial department would take them seriously. "It's so preliminary right now and we don't have the facts — we weren't involved with [what] happened between these researchers," said Kathleen Wren , Science press package director, in a phone interview Nov. 5. "Certainly our editorial department will evaluate this, and the next step is to make sure they have all the relevant facts." The Science editors eventually responded on Nov. 12 by telling Choe's Texas A&M group that it could either contact the Chinese researchers directly or write a formal "Letter to Science" for publication in the journal. The U.S. researchers are currently preparing their official letter to the journal. "Science is a self-correcting enterprise, and the publication of letters to the editor, technical comments, and other responses to original research, including other research papers, are a routine part of the scientific process," Wren said in an e-mail to LiveScience.
x*t
6 楼
12 inch will be too small. I would suggest getting a 16 inch. Go to a store and have your child try them.
冰茶妹妹, 要上16的` 我老大很矮,shortest in her whole classroom 她快4岁的时候,就是去年夏天,我给她买了16"的,当时刚刚够着,今年骑就很自如, 当然,seat是降到最低的。 要是你还不确定,可以带她去 toys R us试一下,看她能够着那个。 尽量买她能够着的最大尺寸,小孩子,长得很快。
【在 l***d 的大作中提到】 : http://www.livescience.com/culture/brain-3d-map-copy-cat-101115.html : Chinese team's brain imaging device has come under question from developers : of a U.S. device who say it's a near duplicate of theirs, LiveScience has : learned. An article on the Chinese device was published in the prestigious : journal Science, and the U.S. researchers are preparing a formal letter to : the journal in response. : According to the report appearing in the Nov. 4 online edition of Science, : the Chinese imaging device used a diamond knife to shave ribbons off a : centimeter-size mouse brain and imaged the slices during the process. That : allowed the Chinese team to create a 3-D map of the brain that revealed
【在 l***d 的大作中提到】 : http://www.livescience.com/culture/brain-3d-map-copy-cat-101115.html : Chinese team's brain imaging device has come under question from developers : of a U.S. device who say it's a near duplicate of theirs, LiveScience has : learned. An article on the Chinese device was published in the prestigious : journal Science, and the U.S. researchers are preparing a formal letter to : the journal in response. : According to the report appearing in the Nov. 4 online edition of Science, : the Chinese imaging device used a diamond knife to shave ribbons off a : centimeter-size mouse brain and imaged the slices during the process. That : allowed the Chinese team to create a 3-D map of the brain that revealed
Qingming Luo one relative or possible relative US Patent first publicated even two year later than TX team' application?! >Inventors: >Chance, Britton (Marathon, FL, US) >Nioka, Shoko (Philadelphia, PA, US) >Luo, Qingming (Philadelphia, PA, US) >Application Number: >10/675597 >Publication Date: >04/01/2004 >Filing Date: >09/27/2003 >Export Citation: >Click for automatic bibliography generation >Primary Class: >600/476 >International Classes: A61B5/00; A61B5/00; (IPC1-7): A61B6/00 View Patent Images: Download PDF 20040064052 from web link: http://www.freepatentsonline.com/y2004/0064052.html but >Inventors: Mccormick, Bruce H. (College Station, TX) Application Number: 09/948469 Publication Date: 06/01/2004 Filing Date: 09/06/2001 Export Citation: Click for automatic bibliography generation Assignee: The Texas A&M University System (College Station, TX) Primary Class: 359/799 Other Classes: 83/73, 83/365, 359/389, 359/809 International Classes: G02B21/00; G02B21/00; (IPC1-7): G02B27/02; B26D5/00; G02B21/02; G02B27/00 Field of Search: 356/606, 83/73, 359/809, 83/856, 359/389, 359/799, 83/365 View Patent Images: Download PDF 6744572 http://www.freepatentsonline.com/6744572.html [PDF] Multiscale Imaging, Analysis, and Integration of Brain Networks - [ Oversett denne siden ] Filformat: PDF/Adobe Acrobat - HTML-versjon Yoonsuck Choe. Brain Networks Laboratory. Department of Computer Science ... Collaborators: Bruce H. McCormick, Louise C. Abbott, John Keyser, (Texas .. .. USPTO patent #US 6744572 (for Knife-Edge. Scanning; 13 claims). McCormick ... http://www.imagwiki.org/mediawiki/images/6/6c/2007MSM_PP_Choe.pdf So relative to above two US patents, it might be not only Luo or Choe's problem also included their former director: Chance, Britton(gone already) or Mccormick, Bruce H Let's await US Science Editors' judgement to this thing.
p*l
34 楼
Lou's patent is on a different technique. I think Lou does not have patent on the technique in the Science paper, but the patent law does not apply to scientific non-profit research. A team in US invented a technique, published it in a so-so journal, but didn 't push it to the level of CNS. Then a team in China reproduced the instrument in their lab without any US help, use it to get wonderful results , and published in CNS. The US can say the China team is copycat, but they may also wonder why they did not push further. The US team has a lot advantages in the race, but they are beaten by the China team. Engineers often think the invention of a technique is the highest point of their research. They tend to think their instruments are their results and anyone rebuild the instrument is not doing innovative research. I guess this is the mind of the US team. But in bioengineering field, an invention without great results will never get into CNS. Getting great results is much harder than proving the instrument works. The China team did the hard work. Whether it worth a Science paper is up to the editor and reviewers, but I don't see them as copycats. A large part of the hard work in this Science paper is indeed labor intense work. I do hope this China team can find their original ideals later. Without original ideals, they will never get a good reputation in the enigeering field.