v*l
2 楼
求Paper, 请发到 j********[email protected] 包子答谢!
PMID: 19546862
[PubMed - indexed for MEDLINE]
Nat Rev Nephrol. 2009 Aug;5(8):441-9. Epub 2009 Jun 23.
The role of transient receptor potential channels in kidney disease.
Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG.
Source
Department of Physiology, Radboud University Nijmegen Medical Centre,
Nijmegen, The Netherlands.
Abstract
The transient receptor potential (TRP) superfamily consists, in mammals, of
six protein subfamilies, TRPC, TRPM, TRPV, TRPA, TRPML and TRPP. TRPs are
cation channels involved in many physiological processes and in the
pathogenesis of various disorders. In the kidney, TRP channels are expressed
along the nephron, and a role for some of these channels in renal function
has been proposed. TRPC3 is thought to facilitate calcium ion influx into
the principal cells of the collecting duct in response to vasopressin. TRPM3
and TRPV4 might be osmosensors, whereas the TRPP1/TRPP2 complex could
function as a mechanosensor in the cilia of renal epithelial cells. A number
of kidney diseases have also been linked to dysfunctional activity of TRPs.
TRPC6 dysfunction has been associated with the onset of focal segmental
glomerosclerosis; TRPP2 dysfunction is linked to autosomal-dominant
polycystic kidney disease, TRPM6 mutations underlie hypomagnesemia with
secondary hypocalcemia, and TRPV1 dysfunction is implicated in renal
hypertension. A link between TRPC1 dysfunction and diabetic nephropathy has
also been suggested in an animal model. Animal studies have implicated a
role for TRPV5 in idiopathic hypercalciuria and vitamin D-dependent rickets,
although these observations have not been confirmed in patients. This
Review focuses on the role of renal TRP channels in health and disease.
PMID: 19546862
[PubMed - indexed for MEDLINE]
Nat Rev Nephrol. 2009 Aug;5(8):441-9. Epub 2009 Jun 23.
The role of transient receptor potential channels in kidney disease.
Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG.
Source
Department of Physiology, Radboud University Nijmegen Medical Centre,
Nijmegen, The Netherlands.
Abstract
The transient receptor potential (TRP) superfamily consists, in mammals, of
six protein subfamilies, TRPC, TRPM, TRPV, TRPA, TRPML and TRPP. TRPs are
cation channels involved in many physiological processes and in the
pathogenesis of various disorders. In the kidney, TRP channels are expressed
along the nephron, and a role for some of these channels in renal function
has been proposed. TRPC3 is thought to facilitate calcium ion influx into
the principal cells of the collecting duct in response to vasopressin. TRPM3
and TRPV4 might be osmosensors, whereas the TRPP1/TRPP2 complex could
function as a mechanosensor in the cilia of renal epithelial cells. A number
of kidney diseases have also been linked to dysfunctional activity of TRPs.
TRPC6 dysfunction has been associated with the onset of focal segmental
glomerosclerosis; TRPP2 dysfunction is linked to autosomal-dominant
polycystic kidney disease, TRPM6 mutations underlie hypomagnesemia with
secondary hypocalcemia, and TRPV1 dysfunction is implicated in renal
hypertension. A link between TRPC1 dysfunction and diabetic nephropathy has
also been suggested in an animal model. Animal studies have implicated a
role for TRPV5 in idiopathic hypercalciuria and vitamin D-dependent rickets,
although these observations have not been confirmed in patients. This
Review focuses on the role of renal TRP channels in health and disease.
s*2
3 楼
yes
a*l
4 楼
s*m
5 楼
thanks
【在 s******2 的大作中提到】
: yes
【在 s******2 的大作中提到】
: yes
a*x
6 楼
能。贵。网上有coupon。还是贵。
【在 s*****m 的大作中提到】
: 算是护照照？
: thanks
【在 s*****m 的大作中提到】
: 算是护照照？
: thanks
a*a
7 楼
自己拍一张，送去CVS 打印，两毛钱吧？
s*m
8 楼
够便宜
【在 a***a 的大作中提到】
: 自己拍一张，送去CVS 打印，两毛钱吧？
【在 a***a 的大作中提到】
: 自己拍一张，送去CVS 打印，两毛钱吧？
a*a
9 楼
再找个CVS 胖子，说不定 到找钱。
【在 s*****m 的大作中提到】
: 够便宜
【在 s*****m 的大作中提到】
: 够便宜
s*m
10 楼
这么好， 能钻几万？
【在 a***a 的大作中提到】
: 再找个CVS 胖子，说不定 到找钱。
【在 a***a 的大作中提到】
: 再找个CVS 胖子，说不定 到找钱。
a*a
11 楼
这个不好说，赚包口香糖还是很有把握的。
【在 s*****m 的大作中提到】
: 这么好， 能钻几万？
【在 s*****m 的大作中提到】
: 这么好， 能钻几万？
k*t
12 楼
还是自己弄吧，这个很简单的。。。。。。。
【在 s*****m 的大作中提到】
: 算是护照照？
: thanks
【在 s*****m 的大作中提到】
: 算是护照照？
: thanks
l*w
13 楼
Try this,
http://photo.iflychina.net
it can make 6 pics (2x2) in a 4x6 photo.
Just go to CVS or Walgreens and print it out, very cheap.
http://photo.iflychina.net
it can make 6 pics (2x2) in a 4x6 photo.
Just go to CVS or Walgreens and print it out, very cheap.
x*u
14 楼
规格是多少？50cm-50cm?
谢谢。
【在 s******2 的大作中提到】
: yes
谢谢。
【在 s******2 的大作中提到】
: yes
l*x
16 楼
50cm?
【在 x*********u 的大作中提到】
: 规格是多少？50cm-50cm?
: 谢谢。
【在 x*********u 的大作中提到】
: 规格是多少？50cm-50cm?
: 谢谢。
p*a
17 楼
50cm-50cm? a poster?
【在 x*********u 的大作中提到】
: 规格是多少？50cm-50cm?
: 谢谢。
【在 x*********u 的大作中提到】
: 规格是多少？50cm-50cm?
: 谢谢。
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