广谱抗病毒药物选择性杀死被感染细胞# Biology - 生物学
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看到一篇发在PLoS One上的小文章，说发明了Broad-Spectrum Antiviral
Therapeutics。
我就是好奇，这东西看起来很酷啊，怎么会发在了PLoS One上？
Todd H. Rider*, Christina E. Zook, Tara L. Boettcher, Scott T. Wick, Jen
nifer S. Pancoast, Benjamin D. Zusman
Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, Ma
ssachusetts, United States of America
Abstract
Currently there are relatively few antiviral therapeutics, and most whic
h do exist are highly pathogen-specific or have other disadvantages. We
have developed a new broad-spectrum antiviral approach, dubbed Double-st
randed RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selective
ly induces apoptosis in cells containing viral dsRNA, rapidly killing in
fected cells without harming uninfected cells. We have created DRACOs an
d shown that they are nontoxic in 11 mammalian cell types and effective
against 15 different viruses, including dengue flavivirus, Amapari and T
acaribe arenaviruses, Guama bunyavirus, and H1N1 influenza. We have also
demonstrated that DRACOs can rescue mice challenged with H1N1 influenza
. DRACOs have the potential to be effective therapeutics or prophylactic
s for numerous clinical and priority viruses, due to the broad-spectrum
sensitivity of the dsRNA detection domain, the potent activity of the ap
optosis induction domain, and the novel direct linkage between the two w
hich viruses have never encountered.
Therapeutics。
我就是好奇，这东西看起来很酷啊，怎么会发在了PLoS One上？
Todd H. Rider*, Christina E. Zook, Tara L. Boettcher, Scott T. Wick, Jen
nifer S. Pancoast, Benjamin D. Zusman
Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, Ma
ssachusetts, United States of America
Abstract
Currently there are relatively few antiviral therapeutics, and most whic
h do exist are highly pathogen-specific or have other disadvantages. We
have developed a new broad-spectrum antiviral approach, dubbed Double-st
randed RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selective
ly induces apoptosis in cells containing viral dsRNA, rapidly killing in
fected cells without harming uninfected cells. We have created DRACOs an
d shown that they are nontoxic in 11 mammalian cell types and effective
against 15 different viruses, including dengue flavivirus, Amapari and T
acaribe arenaviruses, Guama bunyavirus, and H1N1 influenza. We have also
demonstrated that DRACOs can rescue mice challenged with H1N1 influenza
. DRACOs have the potential to be effective therapeutics or prophylactic
s for numerous clinical and priority viruses, due to the broad-spectrum
sensitivity of the dsRNA detection domain, the potent activity of the ap
optosis induction domain, and the novel direct linkage between the two w
hich viruses have never encountered.
