Misleading from Chengfeng Yang's lab(MSU) - 未名空间MITBBS历史存档

国际科技财经博客移民网络热点娱乐民生时事公众号

Redian新闻

>未名空间

>Biology - 生物学

Misleading from Chengfeng Yang's lab(MSU)

Misleading from Chengfeng Yang's lab(MSU)# Biology - 生物学

h*i2011-09-21 07:09

1 楼

又临近一年的年末了，春晚伴随着每一年的开始，也意味着每一年的结束。
一家人团圆喜乐，围在桌前看春晚，春晚似乎已经是中国年不可缺少的一部分。
对于春晚最喜欢的还是喜剧演员带来的小品，这么多年精彩的小品还是会经常拿出来回
味一下，经常还是被逗得捧腹大笑，遗憾的是曾经那些演员已经慢慢的都变老了，有的
甚至已经去世了。
去年还面临这春晚是否应该取消，但是我想春晚已经深深的印在了每一个中国人的心中
，即使节目越来越形式化，但是没有春晚的新年，总是觉得少了什么东西一样。
近两天有网友表示希望潘长江老师不要再上春晚了，已经看的厌烦了，潘长江老师也回
应上不上春晚也不是自己可以说的算的，能不上就尽量不上吧，如果非要求上的话也只
能麻烦你不看了，不看就不烦了。
甚至还有网友因为不满潘长江老师，拿今年的小品学车说事，说重庆公交和辽宁学校门
前车祸的事情，表示潘长江老师应该像全国人民道歉，学车这个小品教唆太多人学车，
才引发的车祸悲剧。
这位网友的脑洞真的是大开，这样八竿子打不着的事情也能强行套在一起，这是没事刷
存在感吗？
有网友甚至表示那现在那么多坐轮椅拄拐的人，难道都要去怪赵本山？
你可以不喜欢，不喜欢可以不看，但是做人一定要有最起码的尊重，至少一位六十岁的
老艺术家原本可以在家享福的，却为了喜剧一直留在舞台，难道我们不应该说声谢谢吗？
老一辈的艺术家年纪已经越来越大，我们不知道还能再看他们这批人表演多久，只是每
一次都心怀感激吧，让我感觉到了小时候的温暖。

s*u2011-09-21 07:09

2 楼

Dr. Samuel M Cohen(Chairman of Department of Pathology, UNMC) wrote a letter to "Toxicological Science" to criticize a misleading from Chengfeng Yang(Michigan State University)lab's a recent paper published in this journal, see below:
Reply to “Reversal and Prevention of Arsenic-Induced Human Bronchial
Epithelial Cell Malignant Transformation by MicroRNA-200b”
1. Samuel M. Cohen1
+ Author Affiliations
1. Department of Pathology and Microbiology, University of Nebraska
Medical Center, Omaha, NE 68198-3135
1. ↵1For correspondence via Fax: (402) 559-8330. E-mail: [email protected]
unmc.edu
Received May 9, 2011.
Accepted May 10, 2011.
In reviewing the article by Wang et al. entitled, “Reversal and Prevention
of Arsenic-Induced Human Bronchial Epithelial Cell Malignant Transformation
by MicroRNA-200b,” I became concerned regarding the pathology of the “
tumors” that grew in the nude mice upon transplantation of bronchial
epithelial cells “transformed” by arsenite in vitro. The documentation of
the pathology consists of a single, small photograph which is difficult to
interpret with regard to the histopathology. Based on appearance, however, I
am concerned that these tumors do not represent bronchial epithelial
malignancies, but rather, either represent inflammatory tissue or
mesenchymal proliferation, either benign or malignant. Whether inflammation
or mesenchymal proliferation, neither would be indicative of an effect that
is representative of the kinds of tumors that occur in humans in response to
arsenic. The authors indicate that there is epithelial to mesenchymal
transformation in vitro, and they take this as a sign of malignant
transformation. However, in reality, that is a late effect in malignant
progression and usually is associated with metastatic growth for lung tumors
. The tumors in humans that are induced by arsenic are all carcinomas. Lung
carcinomas in humans rarely have sarcomatoid (mesenchymal) differentiation,
which represent a rare subtype, and even in those tumors epithelial
differentiation is evident. More substantial evidence should be provided by
the authors that these truly represent epithelial-derived tumors, either
additional histopathology or more definitively by a pankeratin
immunohistochemical stain. Without such documentation, the interpretation of
this article is misleading. If these are not carcinomas, the publication
would be more accurate to indicate that they have produced epithelial to
mesenchymal transformation but that this does not necessarily imply
carcinoma transformation in vitro by arsenite. For comparison, in vitro
transformation of urothelial cells by trivalent arsenicals produced
carcinomas when transplanted into nude mice (Somji et al., 2006; Wnek et al.
, 2010).
A more limited issue that also needs to be addressed is that this
transformation in vitro is only occurring in p53-deficient cells. This is
similar to other in vitro models with arsenic, such as those involving
urothelial UROTsa cells that have been reported by others (Somji et al.,
2006; Wnek et al., 2010). In contrast, individuals who develop tumors in
response to arsenic exposure are usually not p53 deficient nor are many of
the tumors that are induced.

s*u2011-09-21 07:09

3 楼

There are too much misleading in toxicological studies, especially how to
interprete results of animal studies. This is the reason why Dr. Cohen (
Chairman of Department of Pathology, UNMC) wrote this letter to this journal
to expose this misleading.
Chengfeng Yang's profile as below
http://www.psl.msu.edu/yang.html