英国科学家成功用未完全分化的视觉细胞恢复夜盲老鼠的视力 - 未名空间MITBBS历史存档

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英国科学家成功用未完全分化的视觉细胞恢复夜盲老鼠的视力

英国科学家成功用未完全分化的视觉细胞恢复夜盲老鼠的视力# Biology - 生物学

e*52012-04-18 07:04

1 楼

移民部驻香港办事处一份文件透露，2008年以来，来自中国的投资移民申请个案正在「
戏剧性」发展，每年以倍数的速度增长，但发现部分新的案例「并不是非移民加国不可
」，而是为了「规避中国经济变动可能出现的风险」。这些中国投资移民不会有耐性等
5、6年，他们很容易会「变心」去到处理个案更快的新西兰等国，加国必须提高处理速
度来在国际市场「抢中国热钱」。

A*s2012-04-18 07:04

2 楼

就是个广告，没点实质内容，全是水
烦死了，把版面搞得乱七八糟的

s*y2012-04-18 07:04

3 楼

新出的Nature 文章
British scientists have restored the sight of blind
mice by transplanting light-sensitive photoreceptor cells into their eyes.

s*y2012-04-18 07:04

4 楼

Blind' mice eyesight treated with transplanted cells
Lead researcher, Prof Robin Ali , explains the behaviour of blind mice in
the water maze test. Video filmed and produced by UCL and Moorfields
Hospital
Related Stories
British scientists have restored the sight of blind mice by transplanting
light-sensitive photoreceptor cells into their eyes.
The work is a step towards a new treatment for patients with degenerative
eye diseases.
Scientists at University College London Institute of Ophthalmology injected
cells from young healthy mice directly into the retinas of adult mice that
had night-blindness.
The findings are published in Nature.
The cells transplanted were immature rod-photoreceptor cells, which are
especially important for seeing in the dark.
After four to six weeks up to one in six of the transplanted cells had
formed the connections needed to transmit visual information to the brain.
Hidden platform
The researchers tested the vision of the treated mice in a dimly-lit water
maze.
Those mice with transplanted rod cells were able to see a visual cue to find
a hidden platform to enable them to get out of the water. This was in
contrast to untreated mice who found the platform only by chance after
lengthy exploration of the maze.
Prof Robin Ali, at UCL Institute of Ophthalmology and Moorfields Eye
Hospital, who led the research said: "We've shown for the first time that
transplanted photoreceptor cells can integrate successfully with the
existing retinal circuitry and truly improve vision.
“Start Quote
This is a landmark study that will inform future research across a wide
range of fields including vision research, neuroscience and regenerative
medicine”
Dr Rob Buckle Medical Research Council
"We're hopeful that we will soon be able to replicate this success with
photoreceptors derived from embryonic stem cells and eventually to develop
human trials."
Prof Ali said the behavioural maze test was "ultimate proof" that a
significant amount of vision had been restored in the treated mice.
But although the results appear promising, there are still many steps to go
before such a treatment might be suitable for patients.
There are two types of photoreceptor in the eye - rods and cones. It has so
far proved harder to transplant cone photoreceptors - which are crucial for
human sight and tasks like reading.
The scientists also plan to experiment with photoreceptors derived from
embryonic stem cells. Prof Ali said such cell lines already exist but the
question is how efficiently they can transplant them.
Eye The findings could have implications for treating humans
Loss of photoreceptors is the cause of blindness in many human eye diseases
including age-related macular degeneration (AMD), retinitis pigmentosa and
diabetes-related blindness.
But many more animal studies will be needed before such a technique would be
tried with humans.
'Great encouragement'
The research was funded by the Medical Research Council, the Wellcome Trust,
the Royal Society the British Retinitis Pigmentosa Society, Alcon Research
Institute and The Miller's Trust.
Dr Rob Buckle, head of regenerative medicine at the MRC said: "This is a
landmark study that will inform future research across a wide range of
fields including vision research, neuroscience and regenerative medicine.
"It provides clear evidence of functional recovery in the damage eye through
cell transplantation, providing great encouragement for the development of
stem cell therapies to address the many debilitating eye conditions that
affect millions worldwide."
There are already a number of research programmes aiming to treat blindness
using cell transplants.
Last year, the same research group were given the go-ahead to carry out
Europe's first clinical trial involving human embryonic stem cells at
Moorfields Eye Hospital.
That study involves patients with Stargardt's disease, one of the main
causes of blindness in young people. Early results suggest the technique is
safe but reliable results will take several years.

s*y2012-04-18 07:04

5 楼

在该文章中，研究者们使用的是从小鼠里取出来的未完全发育的视觉细胞来移植
到夜盲的成年鼠中。
那些细胞能够正确地找到发育的位置并能正确地和大脑视觉中枢建立起神经联系。
经受处理的老鼠中有近一半得到了rescue.
该实验对退行性视觉丧失的治疗带来了一丝曙光。
虽然在实验中使用的是已经部分分化的体内细胞，但是研究者们下一步会试验使用干细
胞。

injected

【在 s******y 的大作中提到】

: Blind' mice eyesight treated with transplanted cells
: Lead researcher, Prof Robin Ali , explains the behaviour of blind mice in
: the water maze test. Video filmed and produced by UCL and Moorfields
: Hospital
: Related Stories
: British scientists have restored the sight of blind mice by transplanting
: light-sensitive photoreceptor cells into their eyes.
: The work is a step towards a new treatment for patients with degenerative
: eye diseases.
: Scientists at University College London Institute of Ophthalmology injected

O*e2012-04-18 07:04

6 楼

现在这类文章渐渐多了起来，真的很不错。希望有更大的突破。

【在 s******y 的大作中提到】

: 在该文章中，研究者们使用的是从小鼠里取出来的未完全发育的视觉细胞来移植
: 到夜盲的成年鼠中。
: 那些细胞能够正确地找到发育的位置并能正确地和大脑视觉中枢建立起神经联系。
: 经受处理的老鼠中有近一半得到了rescue.
: 该实验对退行性视觉丧失的治疗带来了一丝曙光。
: 虽然在实验中使用的是已经部分分化的体内细胞，但是研究者们下一步会试验使用干细
: 胞。
:
: injected

n*w2012-04-18 07:04

7 楼

He is a very nice guy. He led a very good vision research group at UCL and
they are truly the pioneers of this field.
His biggest contribution so far is to rescue blindness using gene therapy in
humans.
Although he held positiveness for using the cells, he had a strong
preferable opinion over their gene therapy work. [As he sort of indicated in the last paragraph of the paper]
By the way, the first author, who is also a professor, Rachel Pearson is a
very beautiful lady. But she should let her student (the second author) be
the first.
I guess they will be hot in this year's ARVO meeting.