请问有没有GSK3b和proteasome 的促进剂 - 未名空间MITBBS历史存档

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请问有没有GSK3b和proteasome 的促进剂

请问有没有GSK3b和proteasome 的促进剂# Biology - 生物学

i*i2012-06-05 07:06

1 楼

正在研究AKT-ERK-GSK3beta-proteasome pathway，
现在手里有AKT和ERK的inhibitor.我想知道有没有GSK3beta和proteasome的促进剂。也
就是能够稳定gsk3beta，促进proteasome活性的小分子。

i*02012-06-05 07:06

2 楼

that is what everybody want for misfolded protein diseases. According to my
knowledge, there is no compounds directly boosting proteasome function. But
you should thank me that I found during my digging for the unfolded protein
response and ER stress, the Hsp90 inhibitors induce transcription of
molecular chaperones and enhance proteasome activity. It is always easier to
find an inhibitor targeting an enzyme system, but difficult for activators.
I bet you will be reach, if you find a proteasome enhancer.

s*y2012-06-05 07:06

3 楼

能不能推荐一下 Protein misfolding 领域的review article?

my
But
protein
to
activators.

【在 i***0 的大作中提到】

: that is what everybody want for misfolded protein diseases. According to my
: knowledge, there is no compounds directly boosting proteasome function. But
: you should thank me that I found during my digging for the unfolded protein
: response and ER stress, the Hsp90 inhibitors induce transcription of
: molecular chaperones and enhance proteasome activity. It is always easier to
: find an inhibitor targeting an enzyme system, but difficult for activators.
: I bet you will be reach, if you find a proteasome enhancer.