d*7
2 楼
不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
junk dna vs garbage dna”的观点以及探讨读起来很有启发性
这篇不是research article,读起来很enjoyable
http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
One quote from the article:
So, what have we learned from the efforts of 442 researchers consuming 288
million
dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
is the
“Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
ENCODE is
considerably worse than even Apple Maps.
junk dna vs garbage dna”的观点以及探讨读起来很有启发性
这篇不是research article,读起来很enjoyable
http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
One quote from the article:
So, what have we learned from the efforts of 442 researchers consuming 288
million
dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
is the
“Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
ENCODE is
considerably worse than even Apple Maps.
c*e
4 楼
,
No real interesting content.
The author is not happy abut "Big science".
【在 d****7 的大作中提到】
![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
M*7
5 楼
确实是一篇挺有意思的文章,谢谢分享
,
【在 d****7 的大作中提到】![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
,
【在 d****7 的大作中提到】
![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
M*P
6 楼
为什么要说"又"呢?
★ 发自iPhone App: ChineseWeb 7.8
【在 d****7 的大作中提到】![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
★ 发自iPhone App: ChineseWeb 7.8
【在 d****7 的大作中提到】
![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
D*e
7 楼
这篇文章好几个基本常识都错了。。
。。。A scan over all human chromosomes (22 autosomes + X + Y) reveals that
there are 150,281,981 CpG sites。。
作者到底有没有读过ENCODE那一系列的文章啊。。怎么发表的。。
。。。A scan over all human chromosomes (22 autosomes + X + Y) reveals that
there are 150,281,981 CpG sites。。
作者到底有没有读过ENCODE那一系列的文章啊。。怎么发表的。。
M*P
9 楼
这些人理论是不是under selection就没有功能。问题是很多human disease,或者是
human specific 功能就未必是under selection。
encode不用进化作为依据就是为了找到靠进化无法理解的功能片段。当然认为所有open
chromatin都是有功能的也是夸张了。
【在 d****7 的大作中提到】![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
human specific 功能就未必是under selection。
encode不用进化作为依据就是为了找到靠进化无法理解的功能片段。当然认为所有open
chromatin都是有功能的也是夸张了。
【在 d****7 的大作中提到】
![](/moin_static193/solenoid/img/up.png)
: 不知道之前有人发过没,这篇文章从进化的角度来探讨ENCODE里的数据,尤其是对“
: junk dna vs garbage dna”的观点以及探讨读起来很有启发性
: 这篇不是research article,读起来很enjoyable
: http://m.gbe.oxfordjournals.org/content/early/2013/02/20/gbe.ev
: One quote from the article:
: So, what have we learned from the efforts of 442 researchers consuming 288
: million
: dollars? According to Eric Lander, a Human Genome Project luminary, ENCODE
: is the
: “Google Maps of the human genome” (Durbin et al. 2010). We beg to differ,
P*d
10 楼
到底什么是function?白马和马真的不是一个概念,无论内涵还是外延,都不一样。真
的。
的。
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