扯淡一样的故事，关键是不是圈中人，我是捂裆派的。
Science. 2015 Jan 2;347(6217):83-6. doi: 10.1126/science.1258857.
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis
elegans.
Folick A1, Oakley HD2, Yu Y2, Armstrong EH3, Kumari M4, Sanor L5, Moore DD6,
Ortlund EA3, Zechner R4, Wang MC7.
Author information
Abstract
Lysosomes are crucial cellular organelles for human health that function in
digestion and recycling of extracellular and intracellular macromolecules.
We describe a signaling role for lysosomes that affects aging. In the worm
Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear
translocalization of a lysosomal lipid chaperone LBP-8, which promoted
longevity by activating the nuclear hormone receptors NHR-49 and NHR-80. We
used high-throughput metabolomic analysis to identify several lipids in
which abundance was increased in worms constitutively overexpressing LIPL-4.
Among them, oleoylethanolamide directly bound to LBP-8 and NHR-80 proteins,
activated transcription of target genes of NHR-49 and NHR-80, and promoted
longevity in C. elegans. These findings reveal a lysosome-to-nucleus
signaling pathway that promotes longevity and suggest a function of
lysosomes as signaling organelles in metazoans.
Copyright © 2015, American Association for the Advancement of Science.
