Re: 问题？3'UTR# Biology - 生物学
c*t
1 楼
since i'm in this field i think sth should be clarified. so far
the only functional miRNAs has been found in worms and plant
but not in mammlian cells although miRNAs are detected in mammalian
cells. no targets have been found yet. also in worms miRNA (actually
let-7 and lin-4) is not perfectly complenentary to its target
seq at 3'UTR. some bulges exist withink base paring region. this
posts most difficult part to identify potential miRNA target
seq since it's not perfectly match. also miRNA is
the only functional miRNAs has been found in worms and plant
but not in mammlian cells although miRNAs are detected in mammalian
cells. no targets have been found yet. also in worms miRNA (actually
let-7 and lin-4) is not perfectly complenentary to its target
seq at 3'UTR. some bulges exist withink base paring region. this
posts most difficult part to identify potential miRNA target
seq since it's not perfectly match. also miRNA is