MCBJC(Presenilin cofactors in r-secretase)# Biology - 生物学
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Nature 2003 422:438 The role of presenilin cofactors in the
r-secretase complex
Mutations in human presenilin genes have been found linked
to familial Alzheimer disease (AD). Many gene knockout and
transgenic animal models have been developed in order to
understand the pathogenesis of neurodegenerative diseases
such as AD, Huntington disease and Parkinson's disease.
However, these animal models do not faithfully recapitulate
all the aspects of the diseases, probably due to specie
difference, or
r-secretase complex
Mutations in human presenilin genes have been found linked
to familial Alzheimer disease (AD). Many gene knockout and
transgenic animal models have been developed in order to
understand the pathogenesis of neurodegenerative diseases
such as AD, Huntington disease and Parkinson's disease.
However, these animal models do not faithfully recapitulate
all the aspects of the diseases, probably due to specie
difference, or