what is the connection between linkage disequlibrium and GWAS? - 未名空间MITBBS历史存档

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what is the connection between linkage disequlibrium and GWAS?

what is the connection between linkage disequlibrium and GWAS?# Biology - 生物学

x*72010-10-05 07:10

1 楼

【以下文字转载自 Hubei 讨论区】
发信人: xiaxie7 (xiaxie), 信区: Hubei
标题: 一个感觉
发信站: BBS 未名空间站 (Fri Jun 25 15:40:02 2010, 美东)
就是在美国的中餐馆总体上竞争不过欧洲餐馆。
这边中餐馆只有buffet靠较低的价格吸引老美。一般中餐馆的食客都不多。相比之下，
欧洲餐馆经常是
人满为患。
而我在DC吃了法国，希腊等国风味的餐馆，一个人吃一道大菜加免费的面包也就是20美
元不到，但那个
质量比9-12美元的中餐buffet高很多，虾比中餐馆的小很多，但更鲜，蚌比中餐馆的大
很多，也更
甜。

b*t2010-10-05 07:10

2 楼

【以下文字转载自 EmergingNetworking 讨论区】
发信人: boycott (haha), 信区: EmergingNetworking
标题: 有没有股沟工作的来这儿的
发信站: BBS 未名空间站 (Wed Mar 2 20:13:41 2011, 美东)
想问问，股沟怎么把real estate给撤了
网上能找到的评论全都是失望的
非常好用的一个功能，这下没得用了
不知道那个弱智做的决定
http://www.google.com/support/forum/p/maps/thread?tid=41f01a124

l*s2010-10-05 07:10

3 楼

are they related? My teacher asked me to present a paper on GWAS, hopefully
some bullren on this board could share some insight, thanks.

p*e2010-10-05 07:10

4 楼

赞感觉～

【在 x*****7 的大作中提到】

: 【以下文字转载自 Hubei 讨论区】
: 发信人: xiaxie7 (xiaxie), 信区: Hubei
: 标题: 一个感觉
: 发信站: BBS 未名空间站 (Fri Jun 25 15:40:02 2010, 美东)
: 就是在美国的中餐馆总体上竞争不过欧洲餐馆。
: 这边中餐馆只有buffet靠较低的价格吸引老美。一般中餐馆的食客都不多。相比之下，
: 欧洲餐馆经常是
: 人满为患。
: 而我在DC吃了法国，希腊等国风味的餐馆，一个人吃一道大菜加免费的面包也就是20美
: 元不到，但那个

c*x2010-10-05 07:10

5 楼

是版权？

s*02010-10-05 07:10

6 楼

Not quite sure the "connection" you are referring to, but here are my 2cents
, hopefully they will be helpful.
GWAS tests a huge number of SNPs. To control the global significance at
level of 0.05, usually the local significance is calculated through
Bonferroni correction. For example, for a million SNPs to be tested, the
local significance will be set at magnitude of 1e-7. However, not all SNPs
are independent. LD would be observed from nearby SNPs on the same
chromosome, which means the Bonferroni correction appears to be too
stringent and the local significance should be relaxed. Otherwise, the
chance of false negative might dramatically increase.
If several SNPs in a gene have moderate to strong LD with each other and all
show certain levels of association with disease or drug response, that gene
could be of particular interest and is worth further exploration.

hopefully

【在 l*********s 的大作中提到】

: are they related? My teacher asked me to present a paper on GWAS, hopefully
: some bullren on this board could share some insight, thanks.

I*s2010-10-05 07:10

7 楼

定位就不同。

【在 x*****7 的大作中提到】

i*h2010-10-05 07:10

8 楼

MLS' are not vegetarian.

r*l2010-10-05 07:10

9 楼

LD is the non random association between two loci. If one site is your marker and
the other is the causal variance and these two sites are in high LD. Then
you can declare this marker is associated with the phenotype.

hopefully

【在 l*********s 的大作中提到】

: are they related? My teacher asked me to present a paper on GWAS, hopefully
: some bullren on this board could share some insight, thanks.

o*r2010-10-05 07:10

10 楼

LD is the basic for GWAS. Essentially the disease loci won't be typed
directly. However, usually there will be typed SNPs on an array that are
physically close to the disease loci and in strong LD. You can think those
typed SNPs in strong LD as surrogate markers for disease loci.

l*s2010-10-05 07:10

11 楼

thank you for such detailed explanation.

2cents

【在 s*****0 的大作中提到】

: Not quite sure the "connection" you are referring to, but here are my 2cents
: , hopefully they will be helpful.
: GWAS tests a huge number of SNPs. To control the global significance at
: level of 0.05, usually the local significance is calculated through
: Bonferroni correction. For example, for a million SNPs to be tested, the
: local significance will be set at magnitude of 1e-7. However, not all SNPs
: are independent. LD would be observed from nearby SNPs on the same
: chromosome, which means the Bonferroni correction appears to be too
: stringent and the local significance should be relaxed. Otherwise, the
: chance of false negative might dramatically increase.

l*s2010-10-05 07:10

12 楼

thank you for such detailed explanation.

2cents

【在 s*****0 的大作中提到】