"Back in 2009, we wrote a story on crack mobile developer Larva Labs lamenting its inability to make a living off top-rated games in the Android Market. Well, to put it lightly, it ain't 2009 anymore: the Android ecosystem has expanded exponentially in every conceivable direction, the Market has taken on tens of thousands of additional apps, and -- according to one research firm, anyway -- Android has now overtaken BlackBerry to become the most prolific smartphone platform in the US. To that end, Spacetime Studios -- the company behind mobile MMORPG Pocket Legends, which brings in revenue through in-app purchases -- was shocked to discover that it's making some 30 to 50 percent more from its Android users than its iOS ones. Furthermore, they're spending more time playing and downloading the app with far greater frequency, which might be a testament to the fact that really great apps still stand out in the Market better than they do in the more mature (and more populated) App Store. The in-app purchase disparity is a little more difficult to explain, though -- especially since iOS has a slick, integrated purchase mechanism that Google won't be rolling out in Android for a little while yet. At any rate, the online mobile economy -- regardless of platform -- clearly still has some growing, maturing, and stabilizing to do.." http://www.engadget.com/2011/03/09/profit-shocker-android-bring android market share jan.2011
【在 T****n 的大作中提到】 : "Back in 2009, we wrote a story on crack mobile developer Larva Labs : lamenting its inability to make a living off top-rated games in the Android : Market. Well, to put it lightly, it ain't 2009 anymore: the Android : ecosystem has expanded exponentially in every conceivable direction, the : Market has taken on tens of thousands of additional apps, and -- according : to one research firm, anyway -- Android has now overtaken BlackBerry to : become the most prolific smartphone platform in the US. : To that end, Spacetime Studios -- the company behind mobile MMORPG Pocket : Legends, which brings in revenue through in-app purchases -- was shocked to : discover that it's making some 30 to 50 percent more from its Android users
I am not sure that any of these are true. Other than some CNS papers (at least for now), most structures haven't really contributed to 2) and 3) because structure = static picture and life is more dynamic.
【在 h****u 的大作中提到】 : : I am not sure that any of these are true. Other than some CNS papers (at : least for now), most structures haven't really contributed to 2) and 3) : because structure = static picture and life is more dynamic.
其实protein crystallography的原理和显微镜的道理是一模一样的。 "But we can't build an X-ray microscope to look at molecules, for two reasons. First, we don't have an X-ray lens. Second, even if we did have one , it would have to be made with tolerances significantly less than the distance between two atoms! However, we can (in effect) simulate an X-ray lens on a computer. You can think of a microscope as working in two stages. First, light strikes the object and is diffracted in various directions. The lens collects the diffracted rays and reassembles them to form an image. With X-rays, we can detect diffraction from molecules, but we have to use a computer to reassemble the image. It's not quite so simple, but that's the essence of the method."
Because until you really see it, any biochemistry data could be wrong. For instance the ion channel gating, there were already tons of biochemistry data to present multiple mechanisms, but why Nobel price has been given to Rod.
z*g
31 楼
我说的是结构目前的现状。其实你举的这几个例子,用生化,(电)生理,包括突变, 缺失,阻断剂,协同剂已经提供了 general picture。最后的结构解决了精细的details。但没有dynamic东东。其实关于 结构给出全新的功能, 我倒知道两 个。 一个是Ribosome的ribozyme activity,另一个是Ago2 的RNase H like activity . 当然这只是极少数的例子而已。 我并不是对结构有偏见,只是说明事实而已。
这个比较并不恰当。 显微镜可提供in vivo and real time 的dynamics, 而这是体外 生化不能做倒的。结钩到目前还只能提 供静太东东。
one . The a
【在 J********n 的大作中提到】 : 其实protein crystallography的原理和显微镜的道理是一模一样的。 : "But we can't build an X-ray microscope to look at molecules, for two : reasons. First, we don't have an X-ray lens. Second, even if we did have one : , it would have to be made with tolerances significantly less than the : distance between two atoms! However, we can (in effect) simulate an X-ray : lens on a computer. You can think of a microscope as working in two stages. : First, light strikes the object and is diffracted in various directions. The : lens collects the diffracted rays and reassembles them to form an image. : With X-rays, we can detect diffraction from molecules, but we have to use a : computer to reassemble the image. It's not quite so simple, but that's the
p*s
33 楼
I think you are talking about xray, I am not doing that. Even for Xray, you can still get the structures of different intermediate states For dynamics studies, structural methods can do them as well
(at
【在 h****u 的大作中提到】 : : I am not sure that any of these are true. Other than some CNS papers (at : least for now), most structures haven't really contributed to 2) and 3) : because structure = static picture and life is more dynamic.