Nature: Archaic hominin group from Denisova Cave in Siberia - 未名空间MITBBS历史存档

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Nature: Archaic hominin group from Denisova Cave in Siberia

Nature: Archaic hominin group from Denisova Cave in Siberia# Biology - 生物学

g*x2010-12-23 08:12

1 楼

之前有大把的H1b在，才开始工作几天，也没太催公司律师H1B的事。忽然一看10月
份用掉了6000个，只剩下5000个，心一下又慌了。
这种情况下是不是应该申请加急？真得这么快就会用完吗？
还有所谓归智利新加坡的那5000多个，到底用完了多少？没用完也可以其他人用吗
？

h*12010-12-23 08:12

2 楼

本人J1签证，签证到2016年11月份到期，正在申请J1豁免，估计豁免很快就能批下来。
同时我也在办理H1签证，估计今年11月或12月份能办下来。现在J2在国内，请问J2在11
月份前，能否以J2签证来美国？需要去北京的大使馆重新办理签证。如果J2近期来美
国，我的J1豁免是否失效？非常感谢。

g*d2010-12-23 08:12

3 楼

Genetic history of an archaic hominin group from Denisova Cave in
Siberia
David Reich, Richard E. Green, Martin Kircher, Johannes Krause,
Nick Patterson, Eric Y. Durand, Bence Viola, Adrian W. Briggs, Udo
Stenzel, Philip L. F. Johnson, Tomislav Maricic, Jeffrey M. Good,
Tomas Marques-Bonet, Can Alkan, Qiaomei Fu, Swapan Mallick, Heng
Li, Matthias Meyer, Evan E. Eichler, Mark Stoneking, Michael
Richards, Sahra Talamo, Michael V. Shunkov, Anatoli P. Derevianko,
Jean-Jacques Hublin et al.
http://www.nature.com/nature/journal/v468/n7327/full/nature09710.html
http://www.nature.com/news/2010/101222/full/4681012a.html
=====================================
Fossil genome reveals ancestral link
A distant cousin raises questions about human origins.
Ewen Callaway
The ice-age world is starting to look cosmopolitan. While Neanderthals
held sway in Europe and modern humans were beginning to populate the
globe, another ancient human relative lived in Asia, according to a
genome sequence recovered from a finger bone in a cave in southern
Siberia. A comparative analysis of the genome with those of modern
humans suggests that a trace of this poorly understood strand of hominin
lineage survives today, but only in the genes of some Papuans and
Pacific islanders.
A finger bone and a tooth (inset) from Denisova Cave have illuminated a
mysterious strand of hominin.B. VIOLA, MPI EVA
Named after the cave that yielded the 30,000–50,000-year-old bone, the
Denisova nuclear genome follows publication of the same individual's
mitochondrial genome in March1. From that sequence, Svante Pääbo
of the
Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany,
and his colleagues could tell little, except that the individual, now
known to be female, was part of a population long diverged from humans
and Neanderthals.
Her approximately 3-billion-letter nuclear genome, reported in this
issue of Nature2, now provides a more telling glimpse into this
mysterious group. It also raises previously unimagined questions about
its history and relationship to Neanderthals and humans. "The whole
story is incredible. It's like a surprising Christmas present," says
Carles Lalueza Fox, a palaeogeneticist at Pompeu Fabra University in
Barcelona, Spain, who was not involved in the research.
When the ancient genome was compared to a spectrum of modern human
populations, a striking relationship emerged. Unlike most groups,
Melanesians — inhabitants of Papua New Guinea and islands northeast of
Australia — seem to have inherited as much as one-twentieth of their DNA
from Denisovan roots. This suggests that after the ancestors of today's
Papuans split from other human populations and migrated east, they
interbred with Denisovans, but precisely when, where and to what extent
is unclear.
More answers could come from a closer look at Denisovan, human and even
Neanderthal DNA. So far, conclusions about interbreeding have been drawn
from a relatively small number of human genomes using conservative DNA-
analysis methods, says David Reich, a geneticist at Harvard Medical
School in Boston, Massachusetts, who led the Denisova analysis. "There
may have been many more interactions," he says. Pääbo says it may
be
possible to determine roughly when humans interbred with Denisovans by
examining the length of DNA segments lurking in various human genomes,
with shorter segments corresponding to more shuffling of genes and a
longer elapsed time.
A molar discovered in the same cave also yielded mitochondrial DNA
resembling that of the finger bone. But the Denisovans were probably
more widespread, says Pääbo. Some fossils from China, for example,
resemble neither Neanderthals nor modern humans — nor Homo erectus, an
earlier human ancestor. Pääbo wonders whether they could be more
closely
related to Denisovans. His Russian collaborators plan to search for more
complete Denisovan fossils that could be matched to others from China.
Chris Stringer, a palaeoanthropologist at London's Natural History
Museum, agrees that Asian fossils, such as the 200,000-year-old Dali
skull from central China, could have links to the Denisovans. But he
says that firm conclusions about such relationships will have to await
the discovery of more complete Denisovan fossils.
Preserved DNA from other Asian fossils would also provide a clearer
picture of the Denisovans, which Pääbo, to sidestep controversy,
has
opted not to call a new species or subspecies of hominin. The challenge
will be to make sense of such discoveries and put them in the context of
ancient human history, says Lalueza Fox. Palaeoanthropologists are just
beginning to scrutinize the Neanderthal genome published earlier this
year3 for clues to ancient human history. With the Denisova genome,
"they will need to deal with another surprise", he says.
=======================================
Abstract
Using DNA extracted from a finger bone found in Denisova Cave in
southern Siberia, we have sequenced the genome of an archaic hominin to
about 1.9-fold coverage. This individual is from a group that shares a
common origin with Neanderthals. This population was not involved in the
putative gene flow from Neanderthals into Eurasians; however, the data
suggest that it contributed 4–6% of its genetic material to the genomes
of present-day Melanesians. We designate this hominin population
‘Denisovans’ and suggest that it may have been widespread in Asia during
the Late Pleistocene epoch. A tooth found in Denisova Cave carries a
mitochondrial genome highly similar to that of the finger bone. This
tooth shares no derived morphological features with Neanderthals or
modern humans, further indicating that Denisovans have an evolutionary
history distinct from Neanderthals and modern humans.
SOM (free):
http://www.nature.com/nature/journal/v468/n7327/extref/nature09710-
s1.pdf

c*r2010-12-23 08:12

4 楼

别急
6000里面至少有1500要withdraw

s*s2010-12-23 08:12

5 楼

http://dl.dropbox.com/u/2383040/4681012a.pdf
http://dl.dropbox.com/u/2383040/nature09710.pdf

x*z2010-12-23 08:12

6 楼

why do you say that?

【在 c*****r 的大作中提到】

: 别急
: 6000里面至少有1500要withdraw

g*d2010-12-23 08:12

7 楼

Thank you!

【在 s*********s 的大作中提到】

: http://dl.dropbox.com/u/2383040/4681012a.pdf
: http://dl.dropbox.com/u/2383040/nature09710.pdf

i*m2010-12-23 08:12

8 楼

不是说h1b一共是65000吗？现在用了52800，不是只剩下5000个啊？
加急不加急不会影响你占名额的，一旦有receipt就占了名额了，加急不加急只能决定
你拿到receipt到批准要多久。。。

g*x2010-12-23 08:12

9 楼

哦，多谢指点！
还剩5000个的结论是据某律师称，65000里有6,800 件是属于新加坡及智利的H1B1申请。
http://www.mitbbs.com/ym_article/lianglaw/31080957.html

【在 i********m 的大作中提到】

: 不是说h1b一共是65000吗？现在用了52800，不是只剩下5000个啊？
: 加急不加急不会影响你占名额的，一旦有receipt就占了名额了，加急不加急只能决定
: 你拿到receipt到批准要多久。。。

i*m2010-12-23 08:12

10 楼

太恐怖了
你申请得怎样了？LCA递上去了吗？我的还没递呢。。。。

请。

【在 g****x 的大作中提到】

: 哦，多谢指点！
: 还剩5000个的结论是据某律师称，65000里有6,800 件是属于新加坡及智利的H1B1申请。
: http://www.mitbbs.com/ym_article/lianglaw/31080957.html

l*s2010-12-23 08:12

11 楼

请问是否LCA递交并且approve了就算占到名额了吗？还是要把所有的材料递交后才算占
到名额？
谢谢！

【在 i********m 的大作中提到】

c*r2010-12-23 08:12

12 楼

no
until you submit the H1B application and get the receipt

【在 l********s 的大作中提到】

: 请问是否LCA递交并且approve了就算占到名额了吗？还是要把所有的材料递交后才算占
: 到名额？
: 谢谢！

b*s2010-12-23 08:12

13 楼

都是律师故意夸张吓唬你的。现在是年底，哪有公司还在忙着招人、办h1b？至少用到
明年2月份都有名额。

g*32010-12-23 08:12

14 楼

应该是真消息吧

i*m2010-12-23 08:12

15 楼

现在还剩12000是真的
至于智利那6000是怎么回事，希望有牛人过来指点一下。。。。到底能用不？

【在 b**s 的大作中提到】

: 都是律师故意夸张吓唬你的。现在是年底，哪有公司还在忙着招人、办h1b？至少用到
: 明年2月份都有名额。

m*n2010-12-23 08:12

16 楼

那两个小国用的很少，余下的都给其他国家用

【在 i********m 的大作中提到】

: 现在还剩12000是真的
: 至于智利那6000是怎么回事，希望有牛人过来指点一下。。。。到底能用不？

S*Y2010-12-23 08:12

17 楼

so u mean actually it is more than 5000?

【在 m*****n 的大作中提到】

:
: 那两个小国用的很少，余下的都给其他国家用

c*t2010-12-23 08:12

18 楼

请问版主，这两个国家剩下的什么时候能给其它国家用呀？
是不是过了某个deadline，比方说12月1号，这些名额还没用完，就可以给其它国家用
了？

【在 m*****n 的大作中提到】

:
: 那两个小国用的很少，余下的都给其他国家用

c*r2010-12-23 08:12

19 楼

好像是就算剩下也不给别人用

【在 c******t 的大作中提到】

: 请问版主，这两个国家剩下的什么时候能给其它国家用呀？
: 是不是过了某个deadline，比方说12月1号，这些名额还没用完，就可以给其它国家用
: 了？

f*r2010-12-23 08:12

20 楼

可不可以申请2010年10月那次的H1B？就是如果OPT今年7月开始，然后明年初申请，到
明年7月和10月之间有合法的GAP，然后明年10月拿到H1B。这样可以么？

【在 g****x 的大作中提到】

: 哦，多谢指点！
: 还剩5000个的结论是据某律师称，65000里有6,800 件是属于新加坡及智利的H1B1申请。
: http://www.mitbbs.com/ym_article/lianglaw/31080957.html

M*02010-12-23 08:12

21 楼

yes, u can

【在 f****r 的大作中提到】

: 可不可以申请2010年10月那次的H1B？就是如果OPT今年7月开始，然后明年初申请，到
: 明年7月和10月之间有合法的GAP，然后明年10月拿到H1B。这样可以么？

d*e2010-12-23 08:12

22 楼

不会吧？今年现在还能申H1B吗？不是听说到10月1号就不能申了吗？要明年4月才能开
始申？

g*x2010-12-23 08:12

23 楼

不知道呀，公司请的律师email都不回，我都不知道LCA递了没有。
问HR有用马/

【在 i********m 的大作中提到】

: 太恐怖了
: 你申请得怎样了？LCA递上去了吗？我的还没递呢。。。。
:
: 请。

i*m2010-12-23 08:12

24 楼

lz你为啥不直接给律师和hr打电话？
我看到这个消息后今天烦了律师一天了。。。。

m*r2010-12-23 08:12

25 楼

我想知道，现在申请h1b的人，
谁也不知道名额什么时候用完，
如果提交了申请，
可是名额恰好用完了。
岂不是白白浪费了钱而且还拿不到？

【在 i********m 的大作中提到】

: lz你为啥不直接给律师和hr打电话？
: 我看到这个消息后今天烦了律师一天了。。。。