quite a slap on the face hehe. The results also show that the contribution of phenotypic screening to the discovery of first-in-class small-molecule drugs exceeded that of target -based approaches — with 28 and 17 of these drugs coming from the two approaches , respectively — in an era in which the major focus was on target-based approaches. We postulate that a target-centric approach for first-in-class drugs, without consideration of an optimal MMOA, may contribute to the current high attrition rates and low productivity in pharmaceutical research and development. http://www.nature.com/nrd/journal/v10/n7/full/nrd3480.html
x*y
6 楼
Strategy pattern: composition. class storeFormat; class text { public: storeFormat * oneFormat; void store() { oneFormat->store(*this); } } class storeFormat { public: virtual void store(text & oneText) { // default format; } } class format1: public storeFormat { public: virtual void store(text & oneText) { //format1; } } class format2:public storeFormat... .....
I modified the text class to have a storeFormat pointer instead of a storeFormat object. Then, in the class text, you can have two places to set the format: 1. in the initializatoin list after the constructor text::text(storeFormat * aFormat): oneFormat(aFormat){}; 2. a member function you can change the storeFormat in the runntime: void changeFormat(storeFormat* aFormat) { oneFormat = aFormat; } Here, the polymorphism is how to store the text object; Usually, only one object of each format c
Actually, I think it's more like a bridge pattern... Here, it's not about creating parts of a concrete product, so probably Builder doesnot apply very well..
【在 w*****g 的大作中提到】 : How about Builder?
w*t
22 楼
请问是先申请ITIN,还是先开户。我一直理解是先申请ITIN,但是前面的POST FROM PASSWORD,好像是说先开户再申请ITIN。 难道两者都行?
I was about to post it just now!!!!! But I don't have Chinese input..... the only difference is that mine version is 1985..... and I always think of the last two sentences when I clean up my son's poopoo .....
And the girls would say nv ce suo,too, because we don't want to go to nan ce suo, you foolish boys,hahahah......
poopoo
【在 D**********R 的大作中提到】 : I was about to post it just now!!!!! But I don't have Chinese input..... : the only difference is that mine version is 1985..... : and I always think of the last two sentences when I clean up my son's poopoo : .....
说两个我听过的吧。 一个讲一个老头撞了头再也起不来: It’s raining, it’s pouring, The old man is snoring; He went to bed, And bumped his head And couldn’t get up in the morning. 一个讲孩子太多养不活只能饿着睡觉 There was an old woman Who lived in a shoe, She had so many children She didn’t know what to do. She gave them some broth Without any bread. She whipped them all soundly And sent them to bed.
【在 D**********R 的大作中提到】 : I was about to post it just now!!!!! But I don't have Chinese input..... : the only difference is that mine version is 1985..... : and I always think of the last two sentences when I clean up my son's poopoo : .....