will iPS replace ES cells in the future?# Biology - 生物学
e*e
1 楼
最近我要岳母申请探亲签，她的结婚证和房产证学要去公证吗？原件可以不？有没有
XDJM父母最近签过？谢谢！
XDJM父母最近签过？谢谢！
f*x
2 楼
前年爸妈带来个美如画R5，效果不错。但是去年开始，就看不到什么节目了，仅有的几
个节目卡的很厉害。请问，怎么解决这个问题的？如果无解，请推荐播放器，看国内电
视。我家只能用timewarner的网络。谢谢了！
个节目卡的很厉害。请问，怎么解决这个问题的？如果无解，请推荐播放器，看国内电
视。我家只能用timewarner的网络。谢谢了！
o*d
3 楼
要回国给侄子侄女和朋友ipad, 如果在中国想上网不仅用wifi.好象有联通的之类。
那在美国是不是买有网的那种才可以？
Ipad3高清后是不是比ipad2要重了一点？有必要买高清版吗？
还有就是amzaon寄到纽约市是不是也是收税的？
谢谢
那在美国是不是买有网的那种才可以？
Ipad3高清后是不是比ipad2要重了一点？有必要买高清版吗？
还有就是amzaon寄到纽约市是不是也是收税的？
谢谢
e*t
4 楼
seems to have huge debate on this. newbie on stem cells. any comments
welcomed.
welcomed.
O*e
5 楼
几年内是不可能替代的。
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
G*O
6 楼
现在两者不同的证据越来越多。已经不象几年前那么乐观了。
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
G*d
7 楼
re
【在 O******e 的大作中提到】
: 几年内是不可能替代的。
【在 O******e 的大作中提到】
: 几年内是不可能替代的。
e*t
8 楼
any clinical trials going on? on still on bench?
iPS could lead to cancer. that's deadly.
【在 G******O 的大作中提到】
: 现在两者不同的证据越来越多。已经不象几年前那么乐观了。
iPS could lead to cancer. that's deadly.
【在 G******O 的大作中提到】
: 现在两者不同的证据越来越多。已经不象几年前那么乐观了。
n*b
9 楼
"iPSCs is a cancer without any cancer-causing mutation"-God said.
e*t
10 楼
haha, god is right, epigenetics make them cancer, not mutation.
【在 n*********b 的大作中提到】
: "iPSCs is a cancer without any cancer-causing mutation"-God said.
【在 n*********b 的大作中提到】
: "iPSCs is a cancer without any cancer-causing mutation"-God said.
O*e
11 楼
这上帝的英语不过关啊，^_^
【在 n*********b 的大作中提到】
: "iPSCs is a cancer without any cancer-causing mutation"-God said.
【在 n*********b 的大作中提到】
: "iPSCs is a cancer without any cancer-causing mutation"-God said.
V*F
12 楼
haha
【在 O******e 的大作中提到】
: 这上帝的英语不过关啊，^_^
【在 O******e 的大作中提到】
: 这上帝的英语不过关啊，^_^
s*y
13 楼
永远也不可能代替的。iPS细胞明显实用一些。但ES细胞毕竟是真正的胚胎干细胞，也
不会像iPS一像有各种epigenetic memory之类。iPS和ES都离临床太遥远。未分化细胞
的致瘤性总是个大问题。转分化倒是挺有希望
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
不会像iPS一像有各种epigenetic memory之类。iPS和ES都离临床太遥远。未分化细胞
的致瘤性总是个大问题。转分化倒是挺有希望
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
O*e
14 楼
“永远也不可能”的结论，往往都是错的，呵呵
【在 s*****y 的大作中提到】
: 永远也不可能代替的。iPS细胞明显实用一些。但ES细胞毕竟是真正的胚胎干细胞，也
: 不会像iPS一像有各种epigenetic memory之类。iPS和ES都离临床太遥远。未分化细胞
: 的致瘤性总是个大问题。转分化倒是挺有希望
【在 s*****y 的大作中提到】
: 永远也不可能代替的。iPS细胞明显实用一些。但ES细胞毕竟是真正的胚胎干细胞，也
: 不会像iPS一像有各种epigenetic memory之类。iPS和ES都离临床太遥远。未分化细胞
: 的致瘤性总是个大问题。转分化倒是挺有希望
n*k
15 楼
well, it might happen to be a right one...thinking about those disease model
using human cells...BTW, what's ES and what's the usage? anyone remind me:)
))...the same questions with iPS?...hype or hope?
【在 O******e 的大作中提到】
: “永远也不可能”的结论，往往都是错的，呵呵
using human cells...BTW, what's ES and what's the usage? anyone remind me:)
))...the same questions with iPS?...hype or hope?
【在 O******e 的大作中提到】
: “永远也不可能”的结论，往往都是错的，呵呵
y*8
16 楼
For iPS, you might get a cell line from the patient with or without known
mutation, and differentiate it into the disease-related tissue.
Then play with it and call it the disease model. The significance is you
might be able to set up hundreds of lines based on iPS techniques.
model
【在 n********k 的大作中提到】
: well, it might happen to be a right one...thinking about those disease model
: using human cells...BTW, what's ES and what's the usage? anyone remind me:)
: ))...the same questions with iPS?...hype or hope?
mutation, and differentiate it into the disease-related tissue.
Then play with it and call it the disease model. The significance is you
might be able to set up hundreds of lines based on iPS techniques.
model
【在 n********k 的大作中提到】
: well, it might happen to be a right one...thinking about those disease model
: using human cells...BTW, what's ES and what's the usage? anyone remind me:)
: ))...the same questions with iPS?...hype or hope?
n*k
17 楼
Sure, I am with you...I was just reminding onco of those...but still both ES
and iPS for cure are hype, agree? But I am not underestimating the value
of iPS in research etc...It is huge and Shinya definitely deserves Nobel...
【在 y******8 的大作中提到】
: For iPS, you might get a cell line from the patient with or without known
: mutation, and differentiate it into the disease-related tissue.
: Then play with it and call it the disease model. The significance is you
: might be able to set up hundreds of lines based on iPS techniques.
:
: model
and iPS for cure are hype, agree? But I am not underestimating the value
of iPS in research etc...It is huge and Shinya definitely deserves Nobel...
【在 y******8 的大作中提到】
: For iPS, you might get a cell line from the patient with or without known
: mutation, and differentiate it into the disease-related tissue.
: Then play with it and call it the disease model. The significance is you
: might be able to set up hundreds of lines based on iPS techniques.
:
: model
o*4
18 楼
应该没问题
p*r
19 楼
Not in the near future. People now find iPS is really not like ES. Some find
it can turn into cancer.
I think many things need to be sorted out in the next few years.
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
it can turn into cancer.
I think many things need to be sorted out in the next few years.
【在 e*****t 的大作中提到】
: seems to have huge debate on this. newbie on stem cells. any comments
: welcomed.
p*r
20 楼
Agreed. I think we should differentiate ES or iPS outside of body into a
organ, then transplant it in.
ES
【在 n********k 的大作中提到】
: Sure, I am with you...I was just reminding onco of those...but still both ES
: and iPS for cure are hype, agree? But I am not underestimating the value
: of iPS in research etc...It is huge and Shinya definitely deserves Nobel...
organ, then transplant it in.
ES
【在 n********k 的大作中提到】
: Sure, I am with you...I was just reminding onco of those...but still both ES
: and iPS for cure are hype, agree? But I am not underestimating the value
: of iPS in research etc...It is huge and Shinya definitely deserves Nobel...
p*m
21 楼
河马 你那天不是说讨论feeding/obesity来着？你信箱满了 啥时候聊下？
Agreed. I think we should differentiate ES or iPS outside of body into a
organ, then transplant it in.
ES
【在 p*******r 的大作中提到】
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
:
: ES
Agreed. I think we should differentiate ES or iPS outside of body into a
organ, then transplant it in.
ES
【在 p*******r 的大作中提到】
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
:
: ES
n*k
22 楼
I c, just message him through his box... maybe I shall shoot him an email
too
【在 p*****m 的大作中提到】
: 河马 你那天不是说讨论feeding/obesity来着？你信箱满了 啥时候聊下？
:
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
: ES
too
【在 p*****m 的大作中提到】
: 河马 你那天不是说讨论feeding/obesity来着？你信箱满了 啥时候聊下？
:
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
: ES
n*k
23 楼
This is a dream in near future and it really takes a lot, A LOT...maybe some
simpler organs, say joints, or liver?
【在 p*******r 的大作中提到】
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
:
: ES
simpler organs, say joints, or liver?
【在 p*******r 的大作中提到】
: Agreed. I think we should differentiate ES or iPS outside of body into a
: organ, then transplant it in.
:
: ES
j*b
24 楼
Do we find anything new using these disease model?
Majority of the paper only claimed that they found similar phenotypes
reported in mouse model.
【在 y******8 的大作中提到】
: For iPS, you might get a cell line from the patient with or without known
: mutation, and differentiate it into the disease-related tissue.
: Then play with it and call it the disease model. The significance is you
: might be able to set up hundreds of lines based on iPS techniques.
:
: model
Majority of the paper only claimed that they found similar phenotypes
reported in mouse model.
【在 y******8 的大作中提到】
: For iPS, you might get a cell line from the patient with or without known
: mutation, and differentiate it into the disease-related tissue.
: Then play with it and call it the disease model. The significance is you
: might be able to set up hundreds of lines based on iPS techniques.
:
: model
s*s
25 楼
因为刚开始做啊。可以做drug screen啊，比mouse model强多了吧
【在 j*b 的大作中提到】
: Do we find anything new using these disease model?
: Majority of the paper only claimed that they found similar phenotypes
: reported in mouse model.
【在 j*b 的大作中提到】
: Do we find anything new using these disease model?
: Majority of the paper only claimed that they found similar phenotypes
: reported in mouse model.
j*b
26 楼
even if they were the same, there are still tons of problems.The in vitro
differentiation is actually not reliable. A lot of variations,people only
report the good but hide the bad.
【在 G******O 的大作中提到】
: 现在两者不同的证据越来越多。已经不象几年前那么乐观了。
differentiation is actually not reliable. A lot of variations,people only
report the good but hide the bad.
【在 G******O 的大作中提到】
: 现在两者不同的证据越来越多。已经不象几年前那么乐观了。
n*k
27 楼
Sure...nothing is perfect..., Could you let me know what would be a better
alternative when studying the majority of human diseases? ...wish we could
go back to Nazi time, do you?
【在 j*b 的大作中提到】
: even if they were the same, there are still tons of problems.The in vitro
: differentiation is actually not reliable. A lot of variations,people only
: report the good but hide the bad.
alternative when studying the majority of human diseases? ...wish we could
go back to Nazi time, do you?
【在 j*b 的大作中提到】
: even if they were the same, there are still tons of problems.The in vitro
: differentiation is actually not reliable. A lot of variations,people only
: report the good but hide the bad.
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