can someone comment on inhibition of sirtuins and potential applications? - 未名空间MITBBS历史存档

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can someone comment on inhibition of sirtuins and potential applications?

can someone comment on inhibition of sirtuins and potential applications?# Biology - 生物学

c*e2011-09-22 07:09

1 楼

What I know is
The Ugly Truth
He Is Not That Into You
Ritht, man just wants to sleep with you. He just wants to have sex, but
woman wants true love, wants the stable relationship, wants the soulmate.
Different pace between us, that's why we have so many heart-break stories.

P*e2011-09-22 07:09

2 楼

it seems people all focus on sirtuin activators. Not too much work on
inhibition of sirtuins.

A*e2011-09-22 07:09

3 楼

真爱，没有
要真有，也只会保持几秒几分的

【在 c*******e 的大作中提到】

: What I know is
: The Ugly Truth
: He Is Not That Into You
: Ritht, man just wants to sleep with you. He just wants to have sex, but
: woman wants true love, wants the stable relationship, wants the soulmate.
: Different pace between us, that's why we have so many heart-break stories.

l*n2011-09-22 07:09

4 楼

中科院还是医科院院长头一段时间发了一篇circ res,第一作者好像叫li li可以去看看
。

d*92011-09-22 07:09

5 楼

我现在压根都不知道什么是爱了，及其迷茫。我最近都觉得，爱这个东西压根大概就是
人幻想出来了，根本不存在

c*b2011-09-22 07:09

6 楼

nicotinamide啊，可惜不够specific

M*92011-09-22 07:09

7 楼

现在人私心太重，戒心太重。

【在 A*********e 的大作中提到】

: 真爱，没有
: 要真有，也只会保持几秒几分的

P*e2011-09-22 07:09

8 楼

Thanks. But it still seems activation is beneficial in this case. But
inhibition of SIRT2 looks like very promising in neurodegenerative areas.

【在 l******n 的大作中提到】

: 中科院还是医科院院长头一段时间发了一篇circ res,第一作者好像叫li li可以去看看
: 。

d*92011-09-22 07:09

9 楼

因为受过太多伤害

【在 M*********9 的大作中提到】

: 现在人私心太重，戒心太重。

f*42011-09-22 07:09

10 楼

是SIR2 不是SIRT2吧？
外行，不是太懂

【在 P*******e 的大作中提到】

: Thanks. But it still seems activation is beneficial in this case. But
: inhibition of SIRT2 looks like very promising in neurodegenerative areas.

H*r2011-09-22 07:09

11 楼

你想不想要she is not that into you的版本？lol

P*e2011-09-22 07:09

12 楼

Human has SIRT1 to SIRT7. Sir2 is from yeast.

【在 f***4 的大作中提到】

: 是SIR2 不是SIRT2吧？
: 外行，不是太懂

p*h2011-09-22 07:09

13 楼

你真爱的定义是什莫？

l*e2011-09-22 07:09

14 楼

有，还是有的！
外星人都有，何况真爱了！

c*e2011-09-22 07:09

15 楼

10 signs version
“He’s Just Not That Into You” wants to teach the women of this world a
lesson. But you know what? Sometimes us ladies just aren’t that into you,
gentlemen! Guys are just as clueless when it comes to reading the signs.
Some of the best-selling book’s rules hold true for both sexes, like, “if
they only want to see you when they’re drunk,” that’s totally a bad sign
(duh!). However, women have their own set of subtle brush-off techniques.
After countless boring dates and awkward interactions, we’ve decided to let
you studs in on our secrets. We’ve cut through the BS and compiled the
signs that she’s just not that into you.
1. Message in A Message
You call her, you leave a voicemail, and she texts you back. If she really
wanted to reach out and touch someone, she would have rung you.
2. Conflict of Interests
Sure, everyone has a busy schedule, but it’s the quality of the excuse that
counts. If it’s, “I have to clean my apartment,” she doesn’t want to
get dirty with you.
3. Private Eyes
Whether you’re having dinner for two or getting down on the dance floor, if
she’s not looking at you, she’s not looking for you.
4. Please
You’re generous in the sack. She doesn’t return the favor. That’s the
only clue you need.
5. Easy Access
At a party, if she’s talking to Joe Schmo and Wendy Whatsherface more than
she’s chatting with you, you’re nothing special to her.
6. Rider’s Block
You shouldn’t have to jump through hoops to get her to give you the time of
day. If you have plans, and she invites other people along, it’s time to
say bye-bye.
7. Friend in Deed
She tells you what her friends think about you—and it’s not all good. This
level of regurgitation is TMI and intended to drive you out the door.
8. Cuddle Monster
She has sex with you, but that’s it. She’s using you. Say adios—unless
that’s all you want, too.
9. Multiple Choice
If she so much as mentions other sexy guys, you have to forget her—because
she won’t forget about them.
10. Dressed to Kill
From lipstick to low-cut tops, if she never uses any of the tricks of the
lady trade to look her best for you, she doesn’t think you’re worth her
effort.

【在 H**r 的大作中提到】

: 你想不想要she is not that into you的版本？lol

c*e2011-09-22 07:09

16 楼

Five more signs
If you dig a woman who’s behaving in the following ways, the whole pursuit
is probably not worth your time. Yes, women like to be chased, but only by
men they’re actually interested in. This article is for men who already
know the woman – this not for someone you’ve just met online and haven’t
seen face to face; that’s a whole other situation. This is for someone you
’ve actually met.
1. She never asks you to go into detail.
Ok, let me be more specific – she never asks you to go into the details as
they pertain to you, personally. In other words, she doesn’t want to know
anything about you. If she’s a colleague and passes your desk with a “how
was your weekend?” - this means nothing if she doesn’t actually stop and
wait for the answer. Consider anything a less common courtesy and do not
take that as a sign of serious interest. Additionally, if she’s never
actually asked you a question she didn’t need to ask (something about work,
for example) that’s a good sign she’s not interested in you being more
than a colleague.
2. She takes forever to get back to you.
Even a brain surgeon can make time to sms someone. If the woman you lust
after takes a day or two to get back to you, she’s probably not that into
you. Don’t get me wrong, she might be as busy as she says she is. Many
women are. But if a woman likes a man, she will make time for him, no matter
what.
3. She never lets you do her any favors – or she repays them immediately.
This is a sign she knows you’re into her, and she doesn’t want to feel
indebted or obligated to you. Why? Cos that could make her feel like she
owes you something. So if you buy her a cup of coffee one morning, and find
the favor returned before the end of the day, she’s probably clued into
your feelings. Most sane women love it when a man they’re into does
something for them. If the object of your affections does not, she’s either
not interested, or she’s a femnazi. Either way, it’s probably time to
move on.
4. She likes to keep a foot or more of space between you.
Ok – in very rare cases, this can mean a woman is so attracted to you, she
doesn’t trust herself to get any closer. Please realize this usually only
happens in romance novels. If she does everything in her power to keep some
distance between the two of you, this is a good indication she’s not into
you, and doesn’t want to give you the idea she might be.
5. She never makes eye contact for more than a few seconds.
Again, in very rare cases, this could mean she’s really, really into you.
In fact, I tend to get this way myself if I’m really attracted to someone.
However, that’s a rarity, and 98% of the time, if I’m not making eye
contact, it’s cos I want the person in question to go away. If she’s not
looking at you, there’s a reason. And if she’s not giving you other
signals to indicate she’s interested – she’s probably not. So there you
are – 5 signs she’s not interested. As I mentioned, sometimes these can
mean she actually is interested, but I really wouldn’t count on it unless
you see evidence to support that notion.

【在 H**r 的大作中提到】

: 你想不想要she is not that into you的版本？lol

c*e2011-09-22 07:09

17 楼

500 Days of Summer
也是She is not that into you的典范

【在 H**r 的大作中提到】

: 你想不想要she is not that into you的版本？lol

c*e2011-09-22 07:09

18 楼

只是一刹那的感觉
然后又回到现实
好残酷

【在 A*********e 的大作中提到】

: 真爱，没有
: 要真有，也只会保持几秒几分的

c*e2011-09-22 07:09

19 楼

或许有吧对于那些在深宫高墙里成长起来的单纯的王子和公主
衣食无忧的他们或许可以体会到吧

【在 d*******9 的大作中提到】

: 我现在压根都不知道什么是爱了，及其迷茫。我最近都觉得，爱这个东西压根大概就是
: 人幻想出来了，根本不存在

c*e2011-09-22 07:09

20 楼

特别是年纪越大越明显

【在 M*********9 的大作中提到】

: 现在人私心太重，戒心太重。

c*e2011-09-22 07:09

21 楼

变得不相信别人了
不知道这是自身的悲哀还是这个世界的悲哀

【在 d*******9 的大作中提到】

: 因为受过太多伤害

c*e2011-09-22 07:09

22 楼

毫无顾忌的恋爱
除了爱情的悸动什么都不顾
遇事都先考虑对方
轰轰烈烈疯狂的爱一次

【在 p*h 的大作中提到】

: 你真爱的定义是什莫？

c*e2011-09-22 07:09

23 楼

少之又少

【在 l*****e 的大作中提到】

: 有，还是有的！
: 外星人都有，何况真爱了！

p*h2011-09-22 07:09

24 楼

You just need to find the right person.

【在 c*******e 的大作中提到】

: 毫无顾忌的恋爱
: 除了爱情的悸动什么都不顾
: 遇事都先考虑对方
: 轰轰烈烈疯狂的爱一次

a*92011-09-22 07:09

25 楼

相信有爱吧，因为那样感觉比较幸福。。。。。。
不管我错过多少次，我都相信会有一个爱我的，懂我的，无缘无故，我就想对他好的人。
永远都不要放弃希望呀：）

b*e2011-09-22 07:09

26 楼

别说真爱了，我已经好几年都没有那种看到一个人，就迫切的想每时每刻关注他的感觉
了。现在更看重的是我和他在一起，能不能过日子，他能不能当我孩子的爸爸。哎，
觉得自己已经爱无能了。

人。

【在 a***9 的大作中提到】

: 相信有爱吧，因为那样感觉比较幸福。。。。。。
: 不管我错过多少次，我都相信会有一个爱我的，懂我的，无缘无故，我就想对他好的人。
: 永远都不要放弃希望呀：）

a*92011-09-22 07:09

27 楼

我觉得主要是看见一个人，你就用了很高的标准来衡量他
挺喜欢一句话，叫”至道无难，唯嫌拣择”.人这个东西挺有意思的，最忌一开始认识就有了分别之心，喜欢不喜欢，慢慢的认识，慢慢的体会，会发现看上去木讷，不喜欢speak out的人，心里有很大的主意；有些特愤青的人，关键时候也会掉链子。。。。。。
女主人才是一个家庭的灵魂，她一定得是一个很笨的女人，她相信每个人的心里都有一个善良的小角落，连最坏的坏人也想跟她说话；她一定得是一个巧手的女人，至少能糊住丈夫和孩子的嘴，还得会剪个窗花儿；她一定得是个坚强的人，因为有时候男的比我们还脆弱

s*s2011-09-22 07:09

28 楼

Ding this~~~
mm, believe in it. Never ever give up! Even we got hurt, don't lose hope.

人。

【在 a***9 的大作中提到】

s*s2011-09-22 07:09

29 楼

I watched these movies, too, including the '500 days of summer'. Well, think
about the nature of men/women, find the good one among those and don't fall
into the trap, hehe.

【在 c*******e 的大作中提到】

l*m2011-09-22 07:09

30 楼

好像有，但又好像没有 - 似有似无。。。

c*e2011-09-22 07:09

31 楼

找来找去怕最后成了那个走完麦田都没抓到麦穗的那个人

【在 p*h 的大作中提到】

: You just need to find the right person.

c*e2011-09-22 07:09

32 楼

还没有放弃希望只是我怕这个“希望”不会等我结婚了

人。

【在 a***9 的大作中提到】

c*e2011-09-22 07:09

33 楼

快爱无能了因为现在碰到心动的人也会时时想到也会想为他做很多事
可越来越被现实的种种牵绊了没那么肆无忌惮了越来越懂得收敛
既然这么收敛应该已经不是真爱该有的状态吧

【在 b*******e 的大作中提到】

: 别说真爱了，我已经好几年都没有那种看到一个人，就迫切的想每时每刻关注他的感觉
: 了。现在更看重的是我和他在一起，能不能过日子，他能不能当我孩子的爸爸。哎，
: 觉得自己已经爱无能了。
:
: 人。

c*e2011-09-22 07:09

34 楼

现在的社会不管是谁都得学会独立
沟通和交往的确重要这时间里才可以了解到一个人
才会知道是不是真的适合你
当然要在没有掩饰的情况下

识就有了分别之心，喜欢不喜欢，慢慢的认识，慢慢的体会，会发现看上去木讷，不喜
欢speak out的人，心里有很大的主意；有些特愤青的人，关键时候也会掉链子。。。
。。。
一个善良的小角落，连最坏的坏人也想跟她说话；她一定得是一个巧手的女人，至少能
糊住丈夫和孩子的嘴，还得会剪个窗花儿；她一定得是个坚强的人，因为有时候男的比
我们还脆弱

【在 a***9 的大作中提到】

: 我觉得主要是看见一个人，你就用了很高的标准来衡量他
: 挺喜欢一句话，叫”至道无难，唯嫌拣择”.人这个东西挺有意思的，最忌一开始认识就有了分别之心，喜欢不喜欢，慢慢的认识，慢慢的体会，会发现看上去木讷，不喜欢speak out的人，心里有很大的主意；有些特愤青的人，关键时候也会掉链子。。。。。。
: 女主人才是一个家庭的灵魂，她一定得是一个很笨的女人，她相信每个人的心里都有一个善良的小角落，连最坏的坏人也想跟她说话；她一定得是一个巧手的女人，至少能糊住丈夫和孩子的嘴，还得会剪个窗花儿；她一定得是个坚强的人，因为有时候男的比我们还脆弱

c*e2011-09-22 07:09

35 楼

其实已经有点放弃了
我想会因为各方面的压力结婚吧也可能结婚的那个人
并不是自己很喜欢的人而是适合过一生的人

【在 s*********s 的大作中提到】

: Ding this~~~
: mm, believe in it. Never ever give up! Even we got hurt, don't lose hope.
:
: 人。

c*e2011-09-22 07:09

36 楼

Finally, I find I don't know man, don't know what they really want.

think
fall

【在 s*********s 的大作中提到】

: I watched these movies, too, including the '500 days of summer'. Well, think
: about the nature of men/women, find the good one among those and don't fall
: into the trap, hehe.

c*e2011-09-22 07:09

37 楼

还有中间状态啊？

【在 l*****m 的大作中提到】

: 好像有，但又好像没有 - 似有似无。。。

s*s2011-09-22 07:09

38 楼

哎哎，我也是这么想的。女孩就那么几年，没有遇到自己爱，也爱自己的人。就找个爱
自己的人，嫁了吧。。。话说回来，适合过一生的人，没啥不好。如果能找到，适合的
，就是很好了。
推荐LZ听一首歌，《女人心事》
http://www.youtube.com/watch?v=Ls6-hAkAasY&feature=related

【在 c*******e 的大作中提到】

: 其实已经有点放弃了
: 我想会因为各方面的压力结婚吧也可能结婚的那个人
: 并不是自己很喜欢的人而是适合过一生的人

m*e2011-09-22 07:09

39 楼

真爱当然有。。。。

H*r2011-09-22 07:09

40 楼

good

【在 c*******e 的大作中提到】

: 500 Days of Summer
: 也是She is not that into you的典范

c*e2011-09-22 07:09

41 楼

其实很矛盾既然不爱对方怎么会找他即使他喜欢你
不爱他在一起总觉得有地方不对劲
可是一直自己这么撑着也不是个办法
歌不错也贴首歌给单身的男生女生

【在 s*********s 的大作中提到】

: 哎哎，我也是这么想的。女孩就那么几年，没有遇到自己爱，也爱自己的人。就找个爱
: 自己的人，嫁了吧。。。话说回来，适合过一生的人，没啥不好。如果能找到，适合的
: ，就是很好了。
: 推荐LZ听一首歌，《女人心事》
: http://www.youtube.com/watch?v=Ls6-hAkAasY&feature=related

s*y2011-09-22 07:09

42 楼

能不能当孩子他爸有时候比能不能当好男友要求更加高。。我觉得
很多时候自己受委屈了不懂得保护自己，还给这些男生找借口，但奇妙的是，如果我想
想，要是他这样对我们将来的小孩，
我能不能接受，然后答案自己就速递到我面前，就是我绝对不能忍受自己将来的小孩受
这样的“礼遇”。

【在 b*******e 的大作中提到】

s*y2011-09-22 07:09

43 楼

我觉得你说的都是真爱，只是更加成熟的爱。。就像开车戴不戴安全带一样
以前的天真的爱完全飞蛾扑火奋不顾身，把自己弄得焦头烂额。。
现在不会了。。但我觉得这样更加成熟，更懂得保护自己，毕竟爱情真的不是那么虚幻
的东西。。是你的就是你的。也不需
要牺牲其他方面去成全。也不应该过多影响到情绪。应该把它当成奢侈品就好了。有就
锦上添花没有也好好的开开心心过日
子。

【在 c*******e 的大作中提到】

: 快爱无能了因为现在碰到心动的人也会时时想到也会想为他做很多事
: 可越来越被现实的种种牵绊了没那么肆无忌惮了越来越懂得收敛
: 既然这么收敛应该已经不是真爱该有的状态吧

s*y2011-09-22 07:09

44 楼

怎么了。。多上网找找多dating啊。。最重要是保护好自己
但要多尝试。。我不觉得会那么难吧。但我还没开始找。。时候未到时候未到

【在 c*******e 的大作中提到】

: 其实很矛盾既然不爱对方怎么会找他即使他喜欢你
: 不爱他在一起总觉得有地方不对劲
: 可是一直自己这么撑着也不是个办法
: 歌不错也贴首歌给单身的男生女生

S*f2011-09-22 07:09

45 楼

我相信！！！！
因为爱过，所以相信，所以懂得，所以慈悲。。。

L*r2011-09-22 07:09

46 楼

Yes. However, the kindred spirits attract each other.
If you are cynical, do not expect a sun-shine counterpart. If you are vain,
be prepared for skin-deep appreciation and the ugly skeleton in the shiny
closet. If you are are not wise, watch out for the dumb actions from your
chosen one.
You will always make a pair, although you may not appreciate the
interactions and bonds.

【在 c*******e 的大作中提到】