A genes up/down regulated in aCGH result does not equal to its protein expression. I guess only 50% of the expanded genes in aCGH really have significant protein expression. It is what happened to me 2 years ago.
08年有一篇号称cell年度十佳第一的文章就是用这个技术结合RNAi高通量筛选,一下子 找到了十几个oncogene. Please cite this article in press as: Zender et al., An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer, Cell (2008), doi:10.1016/j.cell.2008.09.061