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[八月新番]遗传进化方向的文献推荐
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[八月新番]遗传进化方向的文献推荐# Biology - 生物学
m*g
1 楼
去年11月的时候开始挖坑，那个帖子已经太长了，所以挪个地方继续挖。
感谢大家监督我读文献。
推荐：推荐大家认真读全文
稍微了解一下：可以浏览一下摘要和Figure legend
小知识：看一下摘要就够了
之前发过了这个帖子，但是似乎写了QQ群号什么的触犯了版规吧，所以被删掉了，重新
发一下好了。
欢迎大家回复！可以一起讨论哟（虽然我大部分时候只列个标题）。
范围是Science, Nature和PNAS，虽然Cell也有很多好paper，但时间不够，所以就不专
门看了，有没有人可以推荐一下呢？哈哈。
avatar
m*g
2 楼
PNAS 14.07.29
推荐：
1. Genetic information transfer promotes cooperation in bacteria
小知识：
1. A single macrolichen constitutes hundreds of unrecognized species
avatar
m*g
3 楼
Nature 14.07.31
推荐：
1. Cellular memory erased in human embryos
The DNA methylation landscape of human early embryos
DNA methylation dynamics of the human preimplantation embryo
小知识：
1. Sperm are speedier in groups
avatar
m*g
4 楼
Science 14.08.01
稍微了解一下：
1. An epigenetic window into the past?
2. Extensive transduction of nonrepetitive DNA mediated by L1
retrotransposition in cancer genomes
avatar
m*g
5 楼
PNAS 14.08.05
小知识：
1. Fast running restricts evolutionary change of the vertebral column in
mammals
2. Complete genome of a nonphotosynthetic cyanobacterium in a diatom reveals
recent adaptations to an intracellular lifestyle
avatar
m*g
6 楼
Nature 14.08.07
推荐：
1. Genome-scale functional characterization of Drosophila developmental
enhancers in vivo
小知识：
1. A year with your microbes
2. Tooth structure re-engineered
Replaying evolutionary transitions from the dental fossil record
avatar
m*g
7 楼
Science 14.08.08
稍微了解一下：
1. Modular Evolution of DNA-Binding Preference of a Tbrain Transcription
Factor Provides a Mechanism for Modifying Gene Regulatory Networks
小知识：
1. A fluorescent tool for tagging RNA
2. How to eat poison and get away with it (gut bacteria)
3. In the battle for fitness, being smart doesn't always pay (animal
behavior)
avatar
m*g
8 楼
PNAS 14.08.12
推荐：
1. Network-level architecture and the evolutionary potential of underground
metabolism
小知识：
1. Single-particle tracking reveals that free ribosomal subunits are not
excluded from the Escherichia colinucleoid
avatar
m*g
9 楼
PNAS 14.08.12
推荐：
1. Network-level architecture and the evolutionary potential of underground
metabolism
小知识：
1. Single-particle tracking reveals that free ribosomal subunits are not
excluded from the Escherichia colinucleoid
avatar
m*g
10 楼
PNAS 14.08.12
推荐：
1. Network-level architecture and the evolutionary potential of underground
metabolism
小知识：
1. Single-particle tracking reveals that free ribosomal subunits are not
excluded from the Escherichia colinucleoid
avatar
m*g
11 楼
Nature 14.08.14
稍微了解一下：
1. Historical contingency and its biophysical basis in glucocorticoid
receptor evolution
小知识：
1. CRISPR corrects β-thalassaemia
2. Clonal evolution in breast cancer revealed by single nucleus genome
sequencing
avatar
m*g
12 楼
Science 14.08.15
稍微了解一下：
1. Programmable on-chip DNA compartments as artificial cells
2. Genomic-scale exchange of mRNA between a parasitic plant and its hosts
小知识：
1. You are what you eat, but what about your DNA
2. In utero undernourishment perturbs the adult sperm methylome and
intergenerational metabolism
avatar
m*g
13 楼
PNAS 14.08.19
推荐：
1. Different tradeoffs result from alternate genetic adaptations to a common
environment
稍微了解一下：
1. Pervasive domestication of defective prophages by bacteria
小知识：
1. Artificial selection for structural color on butterfly wings and
comparison with natural evolution
2. Short sequences can efficiently recruit histone H3 lysine 27
trimethylation in the absence of enhancer activity and DNA methylation
avatar
m*g
14 楼
Nature 14.08.21
推荐：
1. Microbiome science needs a healthy dose of scepticism
稍微了解一下：
1. Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the
NMD pathway
小知识：
1. A microbial ecosystem beneath the West Antarctic ice sheet
2. Secret to Ebola’s success
avatar
m*g
15 楼
Science 14.08.22
稍微了解一下：
1. Sensing nectar’s sweetness
Evolution of sweet taste perception in hummingbirds by transformation of the
ancestral umami receptor
小知识：
1. Wolves cooperate but dogs submit, study suggests
2. Reverse-engineering censorship in China Randomized experimentation and
participant observation
3. Early allopolyploid evolution in the post-Neolithic Brassica napus
oilseed genome
avatar
m*g
16 楼
周末不想干活，不开心~
PNAS 14.08.26
稍微了解一下：
1. Enhanced killing of antibiotic-resistant bacteria enabled by massively
parallel combinatorial genetics
avatar
D*a
17 楼
Nature刚发了一篇鱼学走路楼主看了没？我刚下了。。。希望不要攒。。。
Nature. 2014 Aug 27. doi: 10.1038/nature13708.
Developmental plasticity and the origin of tetrapods.
Standen EM1, Du TY2, Larsson HC2.
avatar
m*g
18 楼
Nature 14.08.28
推荐：
1. Genomics: Hiding in plain sight
some updates from ENCODE and modENCODE
其实个人不太喜欢ENCODE的paper
小知识：
1. Sick reefs repel young coral
2. Yeast turned into opioid-makers
3. Behavioural ecology: Love thy neighbour
a model to explain extra-pair copulation in birds
avatar
m*g
19 楼
Science 14.08.29
小知识：
1. Seals infected early Americans with TB
2. The genetic prehistory of the New World Arctic
3. On the origin of Peter Rabbit
4. Targeted enhancement of cortical-hippocampal brain networks and
associative memory
avatar
m*g
20 楼
PNAS 14.09.02
推荐：
1. A critical appraisal of the use of microRNA data in phylogenetics
总结：Highly heterogeneous rates of microRNA gain and loss, pervasive
secondary loss, and sampling error collectively render microRNA-based
inference of phylogeny difficult
稍微了解一下：
1. Introgression in hybrid ants is favored in females but selected against
in males
avatar
m*g
21 楼
刚刚才看到这篇文章，拖延症伤不起啊。
我觉得那个鱼的系统用来做epigenetic analysis，特别是跨代的影响什么的应该会很
有趣呢，最近不是有很多这方面小鼠的文章嘛。
Nature 14.05.13
推荐：
1. How to tame the flood of literature
文献阅读的工具推荐
2. Evolutionary developmental biology: Dynasty of the plastic fish
3. Biological techniques: Edit the genome to understand it
原文：Saturation editing of genomic regions by multiplex homology-directed
repair
稍微了解一下：
1. There is life after academia
10% of the 86,000 current biology PhD students in the United States will
become tenure-track faculty members
小知识：
1. Structural biology: How fluorescent RNA gets its glow

【在 D*a 的大作中提到】
: Nature刚发了一篇鱼学走路楼主看了没？我刚下了。。。希望不要攒。。。
: Nature. 2014 Aug 27. doi: 10.1038/nature13708.
: Developmental plasticity and the origin of tetrapods.
: Standen EM1, Du TY2, Larsson HC2.
avatar
m*g
22 楼
Science 14.09.05
小知识：
1. A long noncoding RNA helps cells divide
2. An edgy way to transform carbon dioxide
catalyst turns CO2 into CO
3. Multiple nutrient stresses at intersecting Pacific Ocean biomes detected
by protein biomarkers
4. The coffee genome provides insight into the convergent evolution of
caffeine biosynthesis
avatar
m*g
23 楼
PNAS 14.09.09
小知识：
1. Fractal branching organizations of Ediacaran rangeomorph fronds reveal a
lost Proterozoic body plan
avatar
m*g
24 楼
Nature 14.09.11
没啥特别感兴趣的呢
小知识：
1. Early diet shapes gut flora
breast-fed vs bottle-fed rhesus
2. Microbiology: Bacteria get vaccinated
by defective phages
3. Viral tagging reveals discrete populations in Synechococcus viral genome
sequence space
4. Gibbon genome and the fast karyotype evolution of small apes
avatar
m*g
25 楼
最近忙着写DDIG去了，一直没看新番~
Science 14.09.12
推荐：
1. RNA and dynamic nuclear organization
Long noncoding RNAs may function as organizing factors that shape the cell
nucleus
稍微了解一下：
1. Enhanced killing of antibiotic-resistant bacteria enabled by massively
parallel combinatorial genetics (PNAS)
avatar
m*g
26 楼
PNAS 14.09.16
稍微了解一下：
1. Single cell sequencing reveals low levels of aneuploidy across mammalian
tissues
Disagrees with previous FISH and SKY results showing high aneuploidy
小知识：
1. Combined fluorescent and electron microscopic imaging unveils the
specific properties of two classes of meiotic crossovers
avatar
m*g
27 楼
Nature 14.09.18
稍微了解一下：
1. Genome sequencing of normal cells reveals developmental lineages and
mutational processes
2. Proteogenomic characterization of human colon and rectal cancer
小知识：
1. The genomic substrate for adaptive radiation in African cichlid fish
2. When disease strikes from nowhere
avatar
m*g
28 楼
Science 14.09.19
小知识：
1. Publication bias in the social sciences: Unlocking the file drawer
2. H3K27me and PRC2 transmit a memory of repression across generations and
during development
avatar
m*g
29 楼
PNAS 14.09.23
稍微了解一下：
1. Evolved tooth gain in sticklebacks is associated with a cis-regulatory
allele of Bmp6
avatar
m*g
30 楼
去年11月的时候开始挖坑，那个帖子已经太长了，所以挪个地方继续挖。
感谢大家监督我读文献。
推荐：推荐大家认真读全文
稍微了解一下：可以浏览一下摘要和Figure legend
小知识：看一下摘要就够了
欢迎大家回复！可以一起讨论哟（虽然我大部分时候只列个标题）。
范围是Science, Nature和PNAS，虽然Cell也有很多好paper，但时间不够，所以就不专
门看了，有没有人可以推荐一下呢？哈哈。
avatar
m*g
31 楼
PNAS 14.07.29
推荐：
1. Genetic information transfer promotes cooperation in bacteria
小知识：
1. A single macrolichen constitutes hundreds of unrecognized species
avatar
m*g
32 楼
Nature 14.07.31
推荐：
1. Cellular memory erased in human embryos
The DNA methylation landscape of human early embryos
DNA methylation dynamics of the human preimplantation embryo
小知识：
1. Sperm are speedier in groups
avatar
m*g
33 楼
Science 14.08.01
稍微了解一下：
1. An epigenetic window into the past?
2. Extensive transduction of nonrepetitive DNA mediated by L1
retrotransposition in cancer genomes
avatar
m*g
34 楼
PNAS 14.08.05
小知识：
1. Fast running restricts evolutionary change of the vertebral column in
mammals
2. Complete genome of a nonphotosynthetic cyanobacterium in a diatom reveals
recent adaptations to an intracellular lifestyle
avatar
m*g
35 楼
Nature 14.08.07
推荐：
1. Genome-scale functional characterization of Drosophila developmental
enhancers in vivo
小知识：
1. A year with your microbes
2. Tooth structure re-engineered
Replaying evolutionary transitions from the dental fossil record
avatar
m*g
36 楼
Science 14.08.08
稍微了解一下：
1. Modular Evolution of DNA-Binding Preference of a Tbrain Transcription
Factor Provides a Mechanism for Modifying Gene Regulatory Networks
小知识：
1. A fluorescent tool for tagging RNA
2. How to eat poison and get away with it (gut bacteria)
3. In the battle for fitness, being smart doesn't always pay (animal
behavior)
avatar
m*g
37 楼
PNAS 14.08.12
推荐：
1. Network-level architecture and the evolutionary potential of underground
metabolism
小知识：
1. Single-particle tracking reveals that free ribosomal subunits are not
excluded from the Escherichia colinucleoid
avatar
m*g
38 楼
Nature 14.08.14
稍微了解一下：
1. Historical contingency and its biophysical basis in glucocorticoid
receptor evolution
小知识：
1. CRISPR corrects β-thalassaemia
2. Clonal evolution in breast cancer revealed by single nucleus genome
sequencing
avatar
m*g
39 楼
Science 14.08.15
稍微了解一下：
1. Programmable on-chip DNA compartments as artificial cells
2. Genomic-scale exchange of mRNA between a parasitic plant and its hosts
小知识：
1. You are what you eat, but what about your DNA
2. In utero undernourishment perturbs the adult sperm methylome and
intergenerational metabolism
avatar
m*g
40 楼
PNAS 14.08.19
推荐：
1. Different tradeoffs result from alternate genetic adaptations to a common
environment
稍微了解一下：
1. Pervasive domestication of defective prophages by bacteria
小知识：
1. Artificial selection for structural color on butterfly wings and
comparison with natural evolution
2. Short sequences can efficiently recruit histone H3 lysine 27
trimethylation in the absence of enhancer activity and DNA methylation
avatar
m*g
41 楼
Nature 14.08.21
推荐：
1. Microbiome science needs a healthy dose of scepticism
稍微了解一下：
1. Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the
NMD pathway
小知识：
1. A microbial ecosystem beneath the West Antarctic ice sheet
2. Secret to Ebola’s success
avatar
m*g
42 楼
Science 14.08.22
稍微了解一下：
1. Sensing nectar’s sweetness
Evolution of sweet taste perception in hummingbirds by transformation of the
ancestral umami receptor
小知识：
1. Wolves cooperate but dogs submit, study suggests
2. Reverse-engineering censorship in China Randomized experimentation and
participant observation
3. Early allopolyploid evolution in the post-Neolithic Brassica napus
oilseed genome
avatar
m*g
43 楼
周末不想干活，不开心~
PNAS 14.08.26
稍微了解一下：
1. Enhanced killing of antibiotic-resistant bacteria enabled by massively
parallel combinatorial genetics
avatar
D*a
44 楼
Nature刚发了一篇鱼学走路楼主看了没？我刚下了。。。希望不要攒。。。
Nature. 2014 Aug 27. doi: 10.1038/nature13708.
Developmental plasticity and the origin of tetrapods.
Standen EM1, Du TY2, Larsson HC2.
avatar
m*g
45 楼
Nature 14.08.28
推荐：
1. Genomics: Hiding in plain sight
some updates from ENCODE and modENCODE
其实个人不太喜欢ENCODE的paper
小知识：
1. Sick reefs repel young coral
2. Yeast turned into opioid-makers
3. Behavioural ecology: Love thy neighbour
a model to explain extra-pair copulation in birds
avatar
m*g
46 楼
Science 14.08.29
小知识：
1. Seals infected early Americans with TB
2. The genetic prehistory of the New World Arctic
3. On the origin of Peter Rabbit
4. Targeted enhancement of cortical-hippocampal brain networks and
associative memory
avatar
m*g
47 楼
PNAS 14.09.02
推荐：
1. A critical appraisal of the use of microRNA data in phylogenetics
总结：Highly heterogeneous rates of microRNA gain and loss, pervasive
secondary loss, and sampling error collectively render microRNA-based
inference of phylogeny difficult
稍微了解一下：
1. Introgression in hybrid ants is favored in females but selected against
in males
avatar
m*g
48 楼
刚刚才看到这篇文章，拖延症伤不起啊。
我觉得那个鱼的系统用来做epigenetic analysis，特别是跨代的影响什么的应该会很
有趣呢，最近不是有很多这方面小鼠的文章嘛。
Nature 14.09.04
推荐：
1. How to tame the flood of literature
文献阅读的工具推荐
2. Evolutionary developmental biology: Dynasty of the plastic fish
3. Biological techniques: Edit the genome to understand it
原文：Saturation editing of genomic regions by multiplex homology-directed
repair
稍微了解一下：
1. There is life after academia
10% of the 86,000 current biology PhD students in the United States will
become tenure-track faculty members
小知识：
1. Structural biology: How fluorescent RNA gets its glow

【在 D*a 的大作中提到】
: Nature刚发了一篇鱼学走路楼主看了没？我刚下了。。。希望不要攒。。。
: Nature. 2014 Aug 27. doi: 10.1038/nature13708.
: Developmental plasticity and the origin of tetrapods.
: Standen EM1, Du TY2, Larsson HC2.
avatar
m*g
49 楼
Science 14.09.05
小知识：
1. A long noncoding RNA helps cells divide
2. An edgy way to transform carbon dioxide
catalyst turns CO2 into CO
3. Multiple nutrient stresses at intersecting Pacific Ocean biomes detected
by protein biomarkers
4. The coffee genome provides insight into the convergent evolution of
caffeine biosynthesis
avatar
m*g
50 楼
PNAS 14.09.09
小知识：
1. Fractal branching organizations of Ediacaran rangeomorph fronds reveal a
lost Proterozoic body plan
avatar
m*g
51 楼
Nature 14.09.11
没啥特别感兴趣的呢
小知识：
1. Early diet shapes gut flora
breast-fed vs bottle-fed rhesus
2. Microbiology: Bacteria get vaccinated
by defective phages
3. Viral tagging reveals discrete populations in Synechococcus viral genome
sequence space
4. Gibbon genome and the fast karyotype evolution of small apes
avatar
m*g
52 楼
最近忙着写DDIG去了，一直没看新番~
Science 14.09.12
推荐：
1. RNA and dynamic nuclear organization
Long noncoding RNAs may function as organizing factors that shape the cell
nucleus
稍微了解一下：
1. Enhanced killing of antibiotic-resistant bacteria enabled by massively
parallel combinatorial genetics (PNAS)
avatar
m*g
53 楼
PNAS 14.09.16
稍微了解一下：
1. Single cell sequencing reveals low levels of aneuploidy across mammalian
tissues
Disagrees with previous FISH and SKY results showing high aneuploidy
小知识：
1. Combined fluorescent and electron microscopic imaging unveils the
specific properties of two classes of meiotic crossovers
avatar
m*g
54 楼
Nature 14.09.18
稍微了解一下：
1. Genome sequencing of normal cells reveals developmental lineages and
mutational processes
2. Proteogenomic characterization of human colon and rectal cancer
小知识：
1. The genomic substrate for adaptive radiation in African cichlid fish
2. When disease strikes from nowhere
avatar
m*g
55 楼
Science 14.09.19
小知识：
1. Publication bias in the social sciences: Unlocking the file drawer
2. H3K27me and PRC2 transmit a memory of repression across generations and
during development
avatar
m*g
56 楼
PNAS 14.09.23
稍微了解一下：
1. Evolved tooth gain in sticklebacks is associated with a cis-regulatory
allele of Bmp6
avatar
m*g
57 楼
Nature 14.09.25
推荐：
Ten Simple Rules for Better Figures (Plos computational biology)
小知识：
1. Antifungal drug resistance evoked via RNAi-dependent epimutations
2.Flu virus comes in various flavours
The composition of a virus differs when in different hosts
avatar
m*g
58 楼
Science 14.09.26
小知识：
Transcriptional diversity during lineage commitment of human blood
avatar
m*g
59 楼
PNAS 14.09.30
稍微了解一下：
1. Ecological and evolutionary significance of genomic GC content diversity
in monocots
GC: higher stability, mutability and cost
flow cytometry to measure GC contents in 239 monocot species
avatar
m*g
60 楼
Nature 14.10.02
推荐：
1. Promoter sequences direct cytoplasmic localization and translation of
mRNAs during starvation in yeast
稍微了解一下：
1. A long noncoding RNA protects the heart from pathological hypertrophy
小知识：
1. Ancient roots of daily rhythm
2. Molecular basis of adaptation to high soil boron in wheat landraces and
elite cultivars
3. Parent-of-origin-specific allelic associations among 106 genomic loci for
age at menarche
avatar
m*g
61 楼
Science 14.10.03
小知识：
1. The littlest patient
Cutting-edge mouse models fuel hope for understanding and treating cancer
2. How large predators manage the cost of hunting
3. How to survive being hot and inebriated
Biofuel, yeast
avatar
m*g
62 楼
PNAS 14.10.07
稍微了解一下：
1. Alternating antibiotic treatments constrain evolutionary paths to
multidrug resistance
小知识：
1. Structural adaptations to diverse fighting styles in sexually selected
weapons
horns morphology in rhinoceros beetle species
avatar
m*g
63 楼
PNAS 14.10.14
稍微了解一下：
1. Erosion of functional independence early in the evolution of a microbial
mutualism
小知识：
1. Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by
maintaining small interfering RNA populations
avatar
m*g
64 楼
上周起进入废柴模式，今天上午终于醒了，ORZ
Nature 14.10.16
稍微了解一下：
1. Of monarchs and migration
The genetics of monarch butterfly migration and warning colouration
小知识：
1. Molecular biology: Genetic touch-ups
some general discussion
2. Site-specific group selection drives locally adapted group compositions
对group selection有兴趣的同学可以看看
avatar
m*g
65 楼
Science 14.10.17
稍微了解一下：
1. Applying evolutionary biology to address global challenges
小知识：
1. Evolution of responses to (un)fairness
2. RNA thermometer controls temperature-dependent virulence factor
expression in Vibrio cholerae
avatar
m*g
66 楼
PNAS 14.10.21
小知识：
1. Allopolyploidy, diversification, and the Miocene grassland expansion
2. Quantitation of interactions between two DNA loops demonstrates loop
domain insulation in E. coli cells
3. Sexual selection on wing interference patterns in Drosophila melanogaster
4. Tug-of-war between driver and passenger mutations in cancer and other
adaptive processes
avatar
m*g
67 楼
Nature 14.10.23
小知识：
1. Obesity link to jet-lagged microbes
2. Oldest-known human genome sequenced
avatar
m*g
68 楼
Science 14.10.24
稍微了解一下：
1. Zooming in to see the bigger picture - Microfluidic and nanofabrication
tools to study bacteria
2. Ratcheting the evolution of multicellularity
小知识：
1. Antheridiogen determines sex in ferns via a spatiotemporally split
gibberellin synthesis pathway
avatar
m*g
69 楼
PNAS 14.10.28
稍微了解一下：
1. Maternal age effect and severe germ-line bottleneck in the inheritance of
human mitochondrial DNA
小知识：
1. Domesticated transposase Kat1 and its fossil imprints induce sexual
differentiation in yeast
avatar
x*6
70 楼
Bounded population sizes, fluctuating selection and the tempo and mode of
coexistence
Using controlled experiments to rigorously test new theory of coexistence.
avatar
M*a
71 楼
2013 article...is it yours?
A good one.

【在 x****6 的大作中提到】
: Bounded population sizes, fluctuating selection and the tempo and mode of
: coexistence
: Using controlled experiments to rigorously test new theory of coexistence.
avatar
x*6
72 楼
Thanks!

【在 M**a 的大作中提到】
: 2013 article...is it yours?
: A good one.
avatar
m*g
73 楼
Nature 14.10.30
稍微了解一下：
1. Geneticists tap human knockouts
小知识：
1. Transcriptional interference by antisense RNA is required for circadian
clock function
2. The top 100 papers
3. Teamwork helps yeast to infect
4. Conditional tolerance of temperate phages via transcription-dependent
CRISPR-Cas targeting
avatar
m*g
74 楼
Science 14.10.31
小知识：
1. Complete pairing not needed
Mechanisms for miRNA targeting
2. A Y-chromosome–encoded small RNA acts as a sex determinant in persimmons
avatar
m*g
75 楼
PNAS 14.11.04
稍微了解一下：
1. Predictable transcriptome evolution in the convergent and complex
bioluminescent organs of squid
avatar
m*g
76 楼
Nature 14.11.06
推荐：
1. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast
and human cells
稍微了解一下：
1. Life cycles, fitness decoupling and the evolution of multicellularity
2. It takes time and a team to win grants
avatar
m*g
77 楼
Science 14.11.07
稍微了解一下：
1. Targeting and plasticity of mitochondrial proteins revealed by proximity-
specific ribosome profiling
Principles of ER cotranslational translocation revealed by proximity-
specific ribosome profiling
小知识：
1. Bats jamming bats: Food competition through sonar interference
avatar
m*g
78 楼
PNAS 14.11.09
小知识：
1. Mating-type switching by chromosomal inversion in methylotrophi yeasts
avatar
m*g
79 楼
Nature 14.11.13
稍微了解一下：
1. Comparative population genomics in animals uncovers the determinants of
genetic diversity
Long-lived or low-fecundity species were less diverse
avatar
m*g
80 楼
Science 14.11.14
稍微了解一下：
1. Genomically encoded analog memory with precise in vivo DNA writing in
living cell populations
Dynamic genome engineering in living cells
小知识：
1. Defining a mesenchymal progenitor niche at single-cell resolution
2. Recombination initiation maps of individual human genomes
avatar
m*g
81 楼
Nature 14.11.20
推荐：
1. Topologically associating domains are stable units of replication-timing
regulation
稍微了解一下：
1. Mice in the ENCODE spotlight
A comparative encyclopedia of DNA elements in the mouse genome
2. Transcript-RNA-templated DNA recombination and repair
小知识：
1. RNA made in its own mirror image
avatar
m*g
82 楼
Science 14.11.21
小知识：
1. How a long-lived fungus keeps mutations in check
2. Mouse regulatory DNA landscapes reveal global principles of cis-
regulatory evolution
avatar
m*g
83 楼
PNAS 14.11.25
小知识：
1. Trajectory and genomic determinants of fungal-pathogen speciation and
host adaptation
avatar
m*g
84 楼
Nature 14.11.27
稍微了解一下：
1. Multiplex single-molecule interaction profiling of DNA-barcoded proteins
avatar
m*g
85 楼
Science 14.11.28
稍微了解一下：
1. The new frontier of genome engineering with CRISPR-Cas9
avatar
N*n
86 楼
这肯定是个女博士，很有闲心。
avatar
m*g
87 楼
Nature 14.12.11
小知识：
1. Regulation of RNA polymerase II activation by histone acetylation in
single living cells
avatar
m*g
88 楼
Nature 14.12.18
稍微了解一下：
1. R-loops induce repressive chromatin marks over mammalian gene terminators
小知识：
1. Modelling human development and disease in pluripotent stem-cell-derived
gastric organoids
2. Cohesin-dependent globules and heterochromatin shape 3D genome
architecture in S. pombe
avatar
m*g
89 楼
Science 14.12.19
推荐：
1. Promoter architecture dictates cell-to-cell variability in gene
expression
稍微了解一下：
1. A designed protein transports ions across a membrane
小知识:
1. Nanovesicles derived from cells of cancer patients carry microRNAs that
initiate tumor growth in normal cells
avatar
m*g
90 楼
PNAS 14.12.30
小知识：
1. Prehistoric genomes reveal the genetic foundation and cost of horse
domestication
avatar
m*g
91 楼
Nature 15.01.01
小知识：
1. Origins of major archaeal clades correspond to gene acquisitions from
bacteria
avatar
m*g
92 楼
Science 15.01.02
小知识：
1. The bad luck of cancer
Variation in cancer risk among tissues can be explained by the number of
stem cell divisions
2. Inching toward the 3D genome
3. Persisters unmasked
4. Smoking is associated with mosaic loss of chromosome Y
avatar
m*g
93 楼
Nature 14.01.08
小知识：
1. The heat released during catalytic turnover enhances the diffusion of an
enzyme
avatar
m*g
94 楼
Science 15.01.09
推荐：
1. The human splicing code reveals new insights into the genetic
determinants of disease
avatar
m*g
95 楼
好久没发帖子，我又来水经验了。
PNAS 15.01.14
稍微了解一下：
1. Directional selection can drive the evolution of modularity in complex
traits
avatar
m*g
96 楼
Nature 15.01.15
稍微了解一下：
1. Long-term phenotypic evolution of bacteria
小知识：
1. Monkey in the mirror
avatar
m*g
97 楼
Science 15.01.16
小知识：
1. Expectations of brilliance underlie gender distributions across academic
disciplines
个人觉得这篇paper就是个噱头……
avatar
m*g
98 楼
PNAS 15.01.20
小知识：
1. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity
mutants
avatar
m*g
99 楼
Nature 15.01.22
小知识：
1. A new antibiotic kills pathogens without detectable resistance
avatar
m*g
100 楼
其实小知识里的paper大概就是用来聊天用的吧，基本都是一些比较好玩的现象
所以其实可以不看。
PNAS 15.01.27
小知识：
1. Aggressive mimicry coexists with mutualism in an aphid
avatar
m*g
101 楼
Nature 15.01.29
推荐：
1. How yeast go multicellular:
Origins of multicellular evolvability in snowflake yeast
稍微了解一下：
1. Genomics: CRISPR engineering turns on genes
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2. Resolving the complexity of the human genome using single-molecule
sequencing
avatar
m*g
102 楼
Science 15.01.30
稍微了解一下：
1. Replication-transcription switch in human mitochondria
小知识：
1. Chicks with a number sense
Number-space mapping in the newborn chick resembles humans’ mental number
line
avatar
m*g
103 楼
PNAS 15.02.03
小知识：
1. Ancestral duplications and highly dynamic opsin gene evolution in
percomorph fishes
2. A comparison of worldwide phonemic and genetic variation in human
populations
avatar
m*g
104 楼
Nature 15.02.13
小知识：
1. Transferred interbacterial antagonism genes augment eukaryotic innate
immune function
2. Recoded organisms engineered to depend on synthetic amino acids
3. Programming - Pick up Python
avatar
m*g
105 楼
Science 15.02.06
推荐：
1. Pervasive degeneracy and epistasis in a protein-protein interface
2. Impact of regulatory variation from RNA to protein
3. Combinatorial labeling of single cells for gene expression cytometry
小知识：
1. Budget for 2016 accentuates the practical
2. Undergraduate research experiences: Impacts and opportunities
avatar
m*g
106 楼
此贴不再更新~ 大家88。Paper还是会看的~但是就懒得发帖啦。最近觉得Cell也挺好看
。基本上扫一期杂志还是很快的。
PS.感觉这个版有的时候氛围很不好，把自身的尖酸刻薄当做见解犀利，把对他人的嘲
讽讥笑当做直言劝谏。有些人表面上狂妄尖锐的话语正好反映出内心的自卑和空虚。我
有时候发发帖就忍不住看看帖，搞得我有时候想问题都变得有些喜欢钻牛角尖了。
我觉得自己70%的可能性是会转行的。为了剩下30%的可能性、个人的兴趣以及对导师的
感激，在努力中。感觉在生物PhD路上走了三年多，从一开始盲目的自信（羞羞地删除
了最开始的帖子）到现在逐渐开始认清现状，一路走来，不能怪谁，当时有好几个人反
对我学生物，我一意孤行。后来出国之后，他们反过来觉得我当时的选择是对的，我自
己却开始有点动摇了。不过接下来也会努力做好的。
大家再见！
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