I predict the clinical/translational studies in the Chinese physiology/ medicine field will have a better chance. 1. ATRA+ATO in APL 2. Artemisinin in malaria
不知道你为什么这么喜欢臆想一些毫无根据的可能,说得越多越当真似的。 Kobilka在Nature发b2AR结构的几乎同时,Raymond Stevens也和他在Science发了两篇 back to back的b2AR结构文章,两人都为通讯作者。之后Stevens又单独或和其他人发 了几篇。Stevens是结构生物学家,以前不做GPCR,也和施一公一样研究很多蛋白结构 ,发了不少CNS。但最后是Kobilka和导师Lefkowitz得了炸药奖,Stevens没得。而 Lefkowitz的工作从来就和b2AR的晶体结构无关。 这是Kobilka和Lefkowitz获诺贝尔奖的原因,30-40年的工作,b2AR结构只是GPCR三个重 大发现中的一个: http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012 "for studies of G-protein–coupled receptors" Lefkowitz started to use radioactivity in 1968 in order to trace cells' receptors. He attached an iodine isotope to various hormones, and thanks to the radiation, he managed to unveil several receptors, among those a receptor for adrenalin: β-adrenergic receptor. His team of researchers extracted the receptor from its hiding place in the cell wall and gained an initial understanding of how it works. The team achieved its next big step during the 1980s. The newly recruited Kobilka accepted the challenge to isolate the gene that codes for the β- adrenergic receptor from the gigantic human genome. His creative approach allowed him to attain his goal. When the researchers analyzed the gene, they discovered that the receptor was similar to one in the eye that captures light. They realized that there is a whole family of receptors that look alike and function in the same manner. Today this family is referred to as G-protein–coupled receptors. About a thousand genes code for such receptors, for example, for light, flavour, odour, adrenalin, histamine, dopamine and serotonin. About half of all medications achieve their effect through G-protein–coupled receptors. The studies by Lefkowitz and Kobilka are crucial for understanding how G- protein–coupled receptors function. Furthermore, in 2011, Kobilka achieved another break-through; he and his research team captured an image of the β- adrenergic receptor at the exact moment that it is activated by a hormone and sends a signal into the cell. This image is a molecular masterpiece – the result of decades of research.
【在 z***k 的大作中提到】 : I predict the clinical/translational studies in the Chinese physiology/ : medicine field will have a better chance. : 1. ATRA+ATO in APL : 2. Artemisinin in malaria
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4.7A 的晶体也能发Science,2013年的 Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer