Interesting study. Whenever the targets/mechanisms of a natural product is discovered, it's a top paper... http://www.cell.com/fulltext/S0092-8674(10)00888-3?switch=standard Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA receptor/sensor. Stimulation of GPR120 with ω-3 FAs or a chemical agonist causes broad anti-inflammatory effects in mono
b*n
4 楼
这人怎么长的像我隔壁实验室的?
i*R
5 楼
有意思. 这的确是个不错的领域。
l*e
6 楼
这个怎么玩儿的?方便,好。
n*k
7 楼
interesting direction...then GPR120 should be in heart, etcetc...
【在 b******d 的大作中提到】 : Interesting study. Whenever the targets/mechanisms of a natural product : is discovered, it's a top paper... : http://www.cell.com/fulltext/S0092-8674(10)00888-3?switch=standard : Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory : effects, but the mechanisms are poorly understood. Here, we show that the : G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA : receptor/sensor. Stimulation of GPR120 with ω-3 FAs or a chemical agonist : causes broad anti-inflammatory effects in mono
C*g
8 楼
s*y
9 楼
Very interesting study! Thanks for sharing
【在 b******d 的大作中提到】 : Interesting study. Whenever the targets/mechanisms of a natural product : is discovered, it's a top paper... : http://www.cell.com/fulltext/S0092-8674(10)00888-3?switch=standard : Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory : effects, but the mechanisms are poorly understood. Here, we show that the : G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA : receptor/sensor. Stimulation of GPR120 with ω-3 FAs or a chemical agonist : causes broad anti-inflammatory effects in mono
s*s
10 楼
偷儿太二
k*o
11 楼
Good paper.Thanks a lot for sharing!!! For this paper itself, it is very important and novel. But it cannot be generalized to "whenever the targets/mechanisms of a natural product is discovered, it's a top paper". It is true that some natural product target, like the most famous TOR ( target of rapamycin), is huge. However, tons of papers with the discovery of novel natural-product target has been published without better recognition. For example, Craig Crews, who has been doing that for his who
e*3
12 楼
不就是lockittight.com吗,早就用了。
b*d
13 楼
discovery of recognition. has There have been two school of people studying this. Crews focuses more on chemistry. In order to get more recognitions, one needs to do more biology to convince biomedical community. nothing against him, just my 2cents.
【在 k*****o 的大作中提到】 : Good paper.Thanks a lot for sharing!!! : For this paper itself, it is very important and novel. But it cannot be : generalized to "whenever the targets/mechanisms of a natural product is : discovered, it's a top paper". : It is true that some natural product target, like the most famous TOR ( : target of rapamycin), is huge. However, tons of papers with the discovery of : novel natural-product target has been published without better recognition. : For example, Craig Crews, who has been doing that for his who
k*o
14 楼
Oh, sorry that I did not make it clear.. I meant "academic recognitions" not "target recognitions"~~ I like Crews work a lot, and I think he deserves more credit. "credit" should have been the word to use (BS my english..||). I guess Schreiber will disagree and say that "more targets could be regulated by one natural product". But compared with synthetic molecules, I always put my bet on natural products.
【在 b******d 的大作中提到】 : : discovery of : recognition. : has : There have been two school of people studying this. Crews focuses more on : chemistry. In order to get more recognitions, one needs to do more : biology to convince biomedical community. nothing against him, just my : 2cents.
b*d
15 楼
Crews been the word to use (BS my english..||). molecules, I Recognitions are related, "target recognitions" will translate to "academic recognitions"..hehe... Indeed, "more targets could be regulated by one natural product". Schreiber is very smart to attract top biologists (half of his lab) back in the days. Similar to what Deng said about cats, no matter what kind of molecule is, synthetic or natural, it's a good one if it has cool biological functions, even better if it could become a drug
【在 k*****o 的大作中提到】 : Oh, sorry that I did not make it clear.. : I meant "academic recognitions" not "target recognitions"~~ I like Crews : work a lot, and I think he deserves more credit. "credit" should have been the word to use (BS my english..||). : I guess Schreiber will disagree and say that "more targets could be : regulated by one natural product". But compared with synthetic molecules, I : always put my bet on natural products.