This Paper Should Not Have Been Published (ZT) - 未名空间MITBBS历史存档

This Paper Should Not Have Been Published (ZT)# Biology - 生物学

d*a2010-12-07 08:12

1 楼

LZ最近刚把phd thesis defense 搞定，按照学校的规定，只能2016年暑假才能拿到最
后那一纸毕业证书了。
但研究生院registrar office可以给开一份证明，好像叫letter of completion，意思
是说达到毕业所有requirements，已经算是phd毕业了。不知道这份证明在申请 O1 和
h1b 时能被接受不？另外，transcript也可以提供。
问了学校的国际学生办公室，说USCIS能接受作为学历证明。不知道各位版上的大拿有
过啥经验不？跪求啊呀呀呀

m*h2010-12-07 08:12

2 楼

破狗的脾气真是好极了

l*e2010-12-07 08:12

3 楼

几乎全新的ThinkPad X200s 7465-CTO，没用过几次，分辨率太高（其实是眼睛不好使）
Intel Core2Duo L9400(1.86GHz, 6MB L2), 2GB DDR3 PC-8500 RAM, 128GB Toshiba
SSD （THNS128GG4BAAA-NonFDE）, 12.1 inch WXGA+ 1440X900 LCD (LED), bgn
wireless, Blue tooth, Modem, 1Gb Ethernet, Secure chip, 9-cell Li-Ion (
panasonic，lasting at least 12 hours), Windows 7 Pro
warranty until 03/12/2011
有意者给个offer吧。

L*O2010-12-07 08:12

4 楼

http://www.slate.com/id/2276919
Scientists see fatal flaws in the NASA study of arsenic-based life.
By Carl ZimmerPosted Tuesday, Dec. 7, 2010, at 10:53 AM ET
On Thursday, Dec. 2, Rosie Redfield sat down to read a new paper called, "A
Bacterium That Can Grow by Using Arsenic Instead of Phosphorus." Despite its
innocuous title, the paper had great ambitions. Every living thing that
scientists have ever studied uses phosphorus to build the backbone of its
DNA. In the new paper, NASA-funded scientists described a microbe that could
use arsenic instead. If the authors of the paper were right, we would have
to expand our notions of what forms life can take.
Redfield, a microbiology professor at the University of British Columbia,
had been hearing rumors about the papers for days beforehand. On Monday,
NASA released a Sphinxlike press release: "NASA will hold a news conference
at 2 p.m. EST on Thursday, Dec. 2, to discuss an astrobiology finding that
will impact the search for evidence of extraterrestrial life." Like a
virulent strain of bacteria, speculation exploded over the next three days.
"Did NASA Discover Life on One of Saturn's Moons?" asked Gawker, a Web site
that does not often ask questions about astrobiology.
The truth was revealed on Thursday. At NASA's press conference, the
scientists described their research, which was just then being posted on the
Web site of the journal Science. They had not found life on one of Saturn's
moons; instead, they had gone to the arsenic-laced waters of Mono Lake in
California and isolated a strain of bacteria they dubbed GFAJ-1.
Back at the lab, they grew the bacteria in a broth of nutrients. When they
gradually reduced the supply of phosphate (a molecule composed of one
phosphorus atom and four oxygen atoms) and replaced it with arsenate (one
arsenic and four oxygen atoms), the bacteria still managed to grow. The
scientists examined the DNA of these hardy microorganisms and inferred that
it contained arsenic.
As soon Redfield started to read the paper, she was shocked. "I was outraged
at how bad the science was," she told me.
Redfield blogged a scathing attack on Saturday. Over the weekend, a few
other scientists took to the Internet as well. Was this merely a case of a
few isolated cranks? To find out, I reached out to a dozen experts on Monday
. Almost unanimously, they think the NASA scientists have failed to make
their case. "It would be really cool if such a bug existed," said San Diego
State University's Forest Rohwer, a microbiologist who looks for new species
of bacteria and viruses in coral reefs. But, he added, "none of the
arguments are very convincing on their own." That was about as positive as
the critics could get. "This paper should not have been published," said
Shelley Copley of the University of Colorado.
None of the scientists I spoke to ruled out the possibility that such weird
bacteria might exist. Indeed, some of them were co-authors of a 2007 report
for the National Academies of Sciences on alien life that called for
research into, among other things, arsenic-based biology. But almost to a
person, they felt that the NASA team had failed to take some basic
precautions to avoid misleading results.
When the NASA scientists took the DNA out of the bacteria, for example, they
ought to have taken extra steps to wash away any other kinds of molecules.
Without these precautions, arsenic could have simply glommed to the DNA,
like gum on a shoe. "It is pretty trivial to do a much better job," said
Rohwer.
In fact, says Harvard microbiologist Alex Bradley, the NASA scientists
unknowingly demonstrated the flaws in their own experiment. They immersed
the DNA in water as they analyzed it, he points out. Arsenic compounds fall
apart quickly in water, so if it really was in the microbe's genes, it
should have broken into fragments, Bradley wrote Sunday in a guest post on
the blog We, Beasties. But the DNA remained in large chunks—presumably
because it was made of durable phosphate. Bradley got his Ph.D. under MIT
professor Roger Summons, a professor at MIT who co-authored the 2007 weird-
life report. Summons backs his former student's critique.
But how could the bacteria be using phosphate when they weren't getting any
in the lab? That was the point of the experiment, after all. It turns out
the NASA scientists were feeding the bacteria salts which they freely admit
were contaminated with a tiny amount of phosphate. It's possible, the
critics argue, that the bacteria eked out a living on that scarce supply. As
Bradley notes, the Sargasso Sea supports plenty of microbes while
containing 300 times less phosphate than was present in the lab cultures.
"Low levels of phosphate in growth media, naive investigators and bad
reviewers are the stories here," said Norman Pace of the University of
Colorado, a pioneer of identifying exotic microbes by analyzing their DNA,
who was another co-author on the weird-life report.
I asked two of the authors of the study if they wanted to respond to the
criticism of their paper. Both politely declined by email.
"We cannot indiscriminately wade into a media forum for debate at this time,
" declared senior author Ronald Oremland of the U.S. Geological Survey. "If
we are wrong, then other scientists should be motivated to reproduce our
findings. If we are right (and I am strongly convinced that we are) our
competitors will agree and help to advance our understanding of this
phenomenon. I am eager for them to do so."
"Any discourse will have to be peer-reviewed in the same manner as our paper
was, and go through a vetting process so that all discussion is properly
moderated," wrote Felisa Wolfe-Simon of the NASA Astrobiology Institute. "
The items you are presenting do not represent the proper way to engage in a
scientific discourse and we will not respond in this manner."
While Redfield considers Wolfe-Simon's research "flim-flam," she think it's
fine for the NASA scientists to hold off responding to their critics. She is
working on a formal letter to Science detailing her objections. But
Jonathan Eisen of UC-Davis doesn't let the scientists off so easily. "If
they say they will not address the responses except in journals, that is
absurd," he said. "They carried out science by press release and press
conference. Whether they were right or not in their claims, they are now
hypocritical if they say that the only response should be in the scientific
literature."
Some scientists are left wondering why NASA made such a big deal over a
paper with so many flaws. "I suspect that NASA may be so desperate for a
positive story that they didn't look for any serious advice from DNA or even
microbiology people," says John Roth of UC-Davis. The experience reminded
some of another press conference NASA held in 1996. Scientists unveiled a
meteorite from Mars in which they said there were microscopic fossils. A
number of critics condemned the report (also published in Science) for
making claims it couldn't back up. And today many scientists think that all
of the alleged signs of life in the rocks could have just as easily been
made on a lifeless planet.
The controversy over the Martian meteorite still sputters on today because
they contain only a few alleged fossils, rather than living bacteria. There
are only a limited number of tests that scientists can run on the rocks, and
their results remain murky. Fortunately, that's not the case for GFAJ-1.
Critics say that a few straightforward tests on the bacteria would show
whether they really do have arsenic-based DNA once and for all. And the NASA
scientists say they're ready to hand out GFAJ-1 to researchers who want to
study it. This controversy may be burning brightly at the moment, but it
probably won't burn for long.

T*02010-12-07 08:12

5 楼

O1不知道，H1B没问题。我朋友硕士学位证都没拿就办H1B，交了证明和成绩单，按照
Adv来抽签。如果你的H1B不涉及抽签（non-profit），那就更加不应该有问题。

n*w2010-12-07 08:12

6 楼

版上那个同学强大的计算应该付上去～～