他们的意思是,神经突触的形成和记忆无关? Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia Shanping Chen, Diancai Cai, Kaycey Pearce, Philip Y W Sun, Adam C Roberts, David L GlanzmanCorresponding Author DOI: http://dx.doi.org/10.7554/eLife.03896Published November 17, 2014 Cite as eLife 2014;10.7554/eLife.03896 Download PDF Abstract Long-term memory (LTM) is believed to be stored in the brain as changes in synaptic connections. Here, we show that LTM storage and synaptic change can be dissociated. Cocultures of Aplysia sensory and motor neurons were trained with spaced pulses of serotonin, which induces long-term facilitation. Serotonin (5HT) triggered growth of new presynaptic varicosities, a synaptic mechanism of long-term sensitization. Following 5HT training, two antimnemonic treatments-reconsolidation blockade and inhibition of PKM-caused the number of presynaptic varicosities to revert to the original, pretraining value. Surprisingly, the final synaptic structure was not achieved by targeted retraction of the 5HT-induced varicosities but , rather, by an apparently arbitrary retraction of both 5HT-induced and original synapses. In addition, we find evidence that the LTM for sensitization persists covertly after its apparent elimination by the same antimnemonic treatments that erase learning-related synaptic growth. These results challenge the idea that stable synapses store long-term memories.
y*i
5 楼
utilities
【在 t****c 的大作中提到】 : 请问一下, : internet 和 Cable 费用在chase expense report里应该归为哪一类? : Work related 还是 online/internet? : 谢谢
z*4
6 楼
快的一塌糊涂,我t60换了ssd以后,就觉得不用更新笔记本了
l*i
7 楼
用海兔做的,怎么说都行
can
【在 s******y 的大作中提到】 : 他们的意思是,神经突触的形成和记忆无关? : Reinstatement of long-term memory following erasure of its behavioral and : synaptic expression in Aplysia : Shanping Chen, Diancai Cai, Kaycey Pearce, Philip Y W Sun, Adam C : Roberts, David L GlanzmanCorresponding Author : DOI: http://dx.doi.org/10.7554/eLife.03896Published November 17, 2014 Cite as eLife 2014;10.7554/eLife.03896 Download PDF : Abstract : Long-term memory (LTM) is believed to be stored in the brain as changes in : synaptic connections. Here, we show that LTM storage and synaptic change can : be dissociated. Cocultures of Aplysia sensory and motor neurons were
可以把单个神经细胞当做一个单片机比如C8051 突触连接 changes in synaptic connections 是计算机总线 而不是 内存结构
can
【在 s******y 的大作中提到】 : 他们的意思是,神经突触的形成和记忆无关? : Reinstatement of long-term memory following erasure of its behavioral and : synaptic expression in Aplysia : Shanping Chen, Diancai Cai, Kaycey Pearce, Philip Y W Sun, Adam C : Roberts, David L GlanzmanCorresponding Author : DOI: http://dx.doi.org/10.7554/eLife.03896Published November 17, 2014 Cite as eLife 2014;10.7554/eLife.03896 Download PDF : Abstract : Long-term memory (LTM) is believed to be stored in the brain as changes in : synaptic connections. Here, we show that LTM storage and synaptic change can : be dissociated. Cocultures of Aplysia sensory and motor neurons were