【 以下文字转载自 Faculty 讨论区 】
发信人: CornucopiaX (丁春秋), 信区: Faculty
标 题: Re: 北大95生物系女生，海归，潜水不幸遇难
发信站: BBS 未名空间站 (Sun Oct 1 12:25:50 2017, 美东)
这个第三作的文章，比较有意思。。 在正常人身上做的这个working memory 的测试，
很有意思。。。这402 healthy adults的取材比较讲究吧，。。她是遗传系的。。为什
么不找家族（pedigree)来做这个实验，这样结果会更丰富。。不是都说，精神病
scheziphina是遗传的吗？
欢迎，各位老师加入讨论啊。。。
Catechol-O-methyltransferase (COMT) genotypes and working memory:
associations with differing cognitive operations.
Bruder GE1, Keilp JG, Xu H, Shikhman M, Schori E, Gorman JM, Gilliam TC.
Author information
Abstract
BACKGROUND:
Catechol-O-methyltransferase (COMT) is a strong candidate gene for
schizophrenia and cognitive functions disrupted in this disorder. This
report examines the relation of COMT genotypes to performance on a battery
of working memory tests differing in the cognitive operations to be
performed on the material.
METHODS:
A large sample of 402 healthy adults were tested on four working memory
tests: Spatial Delayed Response (SDR), Word Serial Position Test (WSPT), N-
back, and Letter-Number Sequencing. A subsample (n = 246) was tested on the
Wisconsin Card Sorting Test (WCST). A saliva swab was used to obtain DNA
from all participants.
RESULTS:
Letter-Number Sequencing, which requires both storage and manipulation of
information, was the only working memory test that showed expected
differences among COMT genotypes, with the met/met group showing the best
performance and the val/val group the poorest performance. As in previous
studies, the met/met group also performed better than the val/val group on
the WCST.
CONCLUSIONS:
COMT genotypes were not associated with performance on tests measuring
simple storage, maintenance of temporal order or updating of information in
working memory. Genotype differences in Letter-Number Sequencing and WCST
suggest that higher-order components of processing (e.g., mental
manipulation) are more closely related to this gene.
