There is lipid (fatty acid) binding site in albumin, and albumin can be phagocytosed by macrophages. http://www.annualreviews.org/doi/abs/10.1146/annurev.immunol.17 I have a question, is the lymph node draining LN? and where are those macropages located in LN? subcapsular sinus, medullary sinus or medullary cord?
多谢!会仔细看文章。 yes, they drained to draining LNs, I normally do tailbase s.c. the lipids end up in inguinal nodes and axilliary nodes. And most of the macrophages ( stained positive for F4/80) are at subcapsular sinus.
LN?
【在 J******s 的大作中提到】 : There is lipid (fatty acid) binding site in albumin, and albumin can be : phagocytosed by macrophages. : http://www.annualreviews.org/doi/abs/10.1146/annurev.immunol.17 : I have a question, : is the lymph node draining LN? and where are those macropages located in LN? : subcapsular sinus, medullary sinus or medullary cord? : : receptor
n*y
21 楼
显然我们是同龄人啊!
【在 m**k 的大作中提到】 : 天,是说 犬笛 么
J*s
22 楼
my question is how lipids meet albumin locally, because albumin should be abundant in blood.
【在 p****e 的大作中提到】 : 是有少部分DC in lymph nodes 也uptake,但大部分都是macrophage,皮下注射2小时 : 后淋巴结里就有大量的lipids,所以主要可能还是lymph node draining而不是兰格汉 : DC transfer.
J*s
23 楼
so lipid binding albumin was from lymph, entered LN through afferent lymphatics.
【在 p****e 的大作中提到】 : 多谢!会仔细看文章。 : yes, they drained to draining LNs, I normally do tailbase s.c. the lipids : end up in inguinal nodes and axilliary nodes. And most of the macrophages ( : stained positive for F4/80) are at subcapsular sinus. : : LN?