北京大学吴虹实验室招聘博士后# Biology - 生物学
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1 楼
岗位一：吴虹课题组博士后工作人员 （2名）
主要职责：
1）独立开展科研工作，动手进行体内外实验；
2）协助PI负责实验室研究课题的设计和开展；
3）参与科研基金撰写；
4）协助培养研究生。
招聘条件：
1）品学兼优，身体健康，年龄在40岁以下；
2）近年来在国内外获得分子生物学、细胞生物学、肿瘤遗传学、药理学等相关专业博
士学位；
3）至少具备一项以下领域内的工作经验和文献发表：
a. 独立运用细胞和动物模型进行肿瘤药物的机理研究
b. 在分子生物学和细胞生物学领域有深厚的知识背景；
c. 在蛋白质分析、核酸分析和细胞生长分析等相关技术方面有丰富的经验；
d. 对治疗癌症的药物疗效和安全性评价方面有强烈的兴趣和研究背景 ；
4）有较强的团队合作精神，沟通协调能力强，动手能力强，工作细心，积极主动，能
持之以恒；
聘用待遇：
本职位将为你提供在生物学领域极具竞争力和创造性的工作机会。博士后工作人员薪酬
标准按照北京大学生命科学院和北大-清华生命科学中心相应规定及个人工作经验及能
力确定。
联系方式：
有意者请将本人应聘材料电子文档发至以下联络方式（请在应聘材料及邮件主题上注明
：姓名 +北大生科吴虹实验室+应聘职位），我们对应聘者进行资格审查。对初审通过
者，将另行通知面试时间。
Email：[email protected]
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代表性科研论文:
1. Katharina Schlacher, Hong Wu and Maria Jasin. A Distinct
Replication Fork Protection Pathway Connects Fanconi Anemia Tumor
Suppressors to RAD51-BRCA1/2. Cancer Cell 2012.
2. D.J. Mulholland, L.M. Tran, Y. Li, H. Cai, A. Morim, S. Wang, S.
Plaisier, I.P. Garraway, J. Huang, T.G. Graeber, and H. Wu. Cell
Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer
Growth. Cancer Cell, 2011. 19(6): p. 792-804.
3. D.J. Mulholland, N Kobayashi, M. Ruscetti, A. Zhi, L. Tran, M.
Johnston, L. Wu, J. Huang, M. Gleave and H. Wu. Pten Loss and RAS/
MAPK activation cooperate to promote EMT and metastatic prostate cancer
initiated from stem/progenitor cells. Cancer Research, 2012. 72 (7).
4. Double-strand break repair-independent role for BRCA2 in blocking
stalled replication fork degradation by MRE11. Schlacher K, Christ N, Siaud
N, Egashira A, Wu H, Jasin M. Cell. 2011
5. Hideaki Tsutsui*, Bahram Valamehr*, Antreas Hindoyan, Rong Qiao,
Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho & Hong Wu.
An optimized small molecule inhibitor cocktail supports long-term
maintenance of human embryonic stem cells. Nat Commun. 2011 Jan;2:167.
6. Wei Guo, Suzanne Schubbert, James Y. Chen, Bahram Valamehr, Sherly
Mosessian, Hubing Shi, Nhi H. Dang, Consuelo Garcia, Mariana F. Theodoro,
Marileila Varella-Garcia, and Hong Wu. Suppression of leukemia
development caused by PTEN loss. PNAS. 2011 Jan 25;108(4):1409-14.
7. Reginald Hill, Joseph Hargan Calvopina, Christine Kim, Ying Wang,
David W. Dawson, Timothy R. Donahue, Sarah Dry, and Hong Wu. PTEN
Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development.
Cancer Res September 15, 2010 70(18).
8. Caroline Gregorian, Jonathan Nakashima, Sarah M. Dry, P. Leia
Nghiemphud, Kate Barzan Smith, Yan Ao, Julie Dang, Gregory Lawson, Ingo K.
Mellinghoff, Paul S. Mischel, Michael Phelps, Luis F. Parada, Xin Liu,
Michael V. Sofroniew, Fritz C. Eilber and Hong Wu. PTEN dosage is
essential for neurofibroma development and malignant transformation.
PNAS November 17, 2009 vol.106 no.46:19479-19484.
9. David J. Mulholland, Li Xin, Ashkan Morim, Devon Lawson, Owen Witte,
and Hong Wu Lin-Sca-1+CD49f high stem/progenitors are tumor-
initiating cells in the Pten-null prostate cancer model. Cancer Res.
2009 Nov 15;69(22):8555-62.
10. Caroline Gregorian, Jonathan Nakashima, Janel Le Belle, John Ohab,
Rachel Kim, Annie Liu, Kate Barzan Smith, Matthias Groszer, A. Denise Garcia
, Michael V. Sofroniew, S. Thomas Carmichael, Harley I. Kornblum, Xin Liu,
and Hong Wu Pten deletion in adult neural stem/progenitor cells
enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):
1874-86.
11. Bahram Valamehr, Steven J. Jonas, Julien Polleux, Rong Qiao, Shuling
Guo, Eric H. Gschweng, Bangyan Stiles, Korey Kam, Tzy-Jiun M. Luo, Owen N.
Witte, Xin Liu, Bruce Dunn, and Hong Wu Hydrophobic surfaces for
enhanced differentiation of embryonic stem cell-derived embryoid bodies
8232;PNAS, 12 September 2008.
12. Wei Guo, Joseph L. Lasky, Chun-Ju Chang, SherlyMosessian, Xiaoman
Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe,
MarileilaVarella-Garcia & Hong Wu Multi-genetic events
collaboratively contribute to Pten-null leukaemia stem-cell formation .
8232; Nature 2008 May 22;453(7194):529-33.
13. Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON,
Liu X, Wu H NKX3.1 stabilizes p53, inhibits AKT activation, and
blocks prostate cancer initiation caused by PTEN loss. Cancer Cell.
2006 May;9(5):367-78.
14. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J,
Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively
regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
. PNAS. 2006 Jan 3;103(1):111-6
15. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y,
Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA,
Dor Y Pten constrains centroacinar cell expansion and malignant
transformation in the pancreas. Cancer Cell. 2005 Sep;8(3):185-95.
16. Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li
G, Roy-Burman P, Nelson PS, Liu X, Wu H. Prostate-specific deletion
of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
. Cancer Cell. 2003 Sep;4(3):209-21.
17. Tsai PT, Lee RA, Wu H. BMP4 acts upstream of FGF in modulating
thymic stroma and regulating thymopoiesis. Blood. 2003 Aug 14
18. Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD,
Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H. PTEN tumor
suppressor regulates p53 protein levels and activity through phosphatase-
dependent and -independent mechanisms. Cancer Cell. 2003 Feb;3(2):117
-30.
19. Anzelon AN, Wu H, Rickert RC. Pten inactivation alters
peripheral B lymphocyte fate and reconstitutes CD19 function. Nat
Immunol. 2003 Mar;4(3):287-94.
20. Jegalian AG, Acurio A, Dranoff G, Wu H. Erythropoietin
receptor haploinsufficiency and in vivo interplay with granulocyte-
macrophage colony-stimulating factor and interleukin 3. Blood. 2002
Apr 1;99(7):2603-5.
21. Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack
JA, Kornblum HI, Liu X, Wu H. Negative regulation of neural stem/
progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
8232;Science. 2001 Dec 7;294(5549):2186-9
22. Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H. Erythropoietin
(Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001
Sep 1;98(5):1408-15.
23. Liliental,J., Lesche, R., Moon, S-Y., Mamillapalli, R., Gavrilova, N.
, Sun, H., Zheng, Y., and Wu, H. Genetic Deletion of the Pten Tumor
Suppressor Gene Promotes Cell Motility by Activation of Rac1 and Cdc42
GTPases. Curr Biol. 2000 Apr 6;10(7):401-4.
24. Sun, H., Lesche, R., Li, DM., Liliental, J., Zhang, H., Gao, J.,
Garvarina, N., Mueller, B., Liu, X. and Wu, H. PTEN Modulates Cell
Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling
Pathway. PNAS. 1999 May 25;96(11):6199-204.
主要职责：
1）独立开展科研工作，动手进行体内外实验；
2）协助PI负责实验室研究课题的设计和开展；
3）参与科研基金撰写；
4）协助培养研究生。
招聘条件：
1）品学兼优，身体健康，年龄在40岁以下；
2）近年来在国内外获得分子生物学、细胞生物学、肿瘤遗传学、药理学等相关专业博
士学位；
3）至少具备一项以下领域内的工作经验和文献发表：
a. 独立运用细胞和动物模型进行肿瘤药物的机理研究
b. 在分子生物学和细胞生物学领域有深厚的知识背景；
c. 在蛋白质分析、核酸分析和细胞生长分析等相关技术方面有丰富的经验；
d. 对治疗癌症的药物疗效和安全性评价方面有强烈的兴趣和研究背景 ；
4）有较强的团队合作精神，沟通协调能力强，动手能力强，工作细心，积极主动，能
持之以恒；
聘用待遇：
本职位将为你提供在生物学领域极具竞争力和创造性的工作机会。博士后工作人员薪酬
标准按照北京大学生命科学院和北大-清华生命科学中心相应规定及个人工作经验及能
力确定。
联系方式：
有意者请将本人应聘材料电子文档发至以下联络方式（请在应聘材料及邮件主题上注明
：姓名 +北大生科吴虹实验室+应聘职位），我们对应聘者进行资格审查。对初审通过
者，将另行通知面试时间。
Email：[email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(c);}s=document.createTextNode(s);l.parentNode.replaceChild(s,l);}}catch(e){}})();
/* ]]> */
代表性科研论文:
1. Katharina Schlacher, Hong Wu and Maria Jasin. A Distinct
Replication Fork Protection Pathway Connects Fanconi Anemia Tumor
Suppressors to RAD51-BRCA1/2. Cancer Cell 2012.
2. D.J. Mulholland, L.M. Tran, Y. Li, H. Cai, A. Morim, S. Wang, S.
Plaisier, I.P. Garraway, J. Huang, T.G. Graeber, and H. Wu. Cell
Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer
Growth. Cancer Cell, 2011. 19(6): p. 792-804.
3. D.J. Mulholland, N Kobayashi, M. Ruscetti, A. Zhi, L. Tran, M.
Johnston, L. Wu, J. Huang, M. Gleave and H. Wu. Pten Loss and RAS/
MAPK activation cooperate to promote EMT and metastatic prostate cancer
initiated from stem/progenitor cells. Cancer Research, 2012. 72 (7).
4. Double-strand break repair-independent role for BRCA2 in blocking
stalled replication fork degradation by MRE11. Schlacher K, Christ N, Siaud
N, Egashira A, Wu H, Jasin M. Cell. 2011
5. Hideaki Tsutsui*, Bahram Valamehr*, Antreas Hindoyan, Rong Qiao,
Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho & Hong Wu.
An optimized small molecule inhibitor cocktail supports long-term
maintenance of human embryonic stem cells. Nat Commun. 2011 Jan;2:167.
6. Wei Guo, Suzanne Schubbert, James Y. Chen, Bahram Valamehr, Sherly
Mosessian, Hubing Shi, Nhi H. Dang, Consuelo Garcia, Mariana F. Theodoro,
Marileila Varella-Garcia, and Hong Wu. Suppression of leukemia
development caused by PTEN loss. PNAS. 2011 Jan 25;108(4):1409-14.
7. Reginald Hill, Joseph Hargan Calvopina, Christine Kim, Ying Wang,
David W. Dawson, Timothy R. Donahue, Sarah Dry, and Hong Wu. PTEN
Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development.
Cancer Res September 15, 2010 70(18).
8. Caroline Gregorian, Jonathan Nakashima, Sarah M. Dry, P. Leia
Nghiemphud, Kate Barzan Smith, Yan Ao, Julie Dang, Gregory Lawson, Ingo K.
Mellinghoff, Paul S. Mischel, Michael Phelps, Luis F. Parada, Xin Liu,
Michael V. Sofroniew, Fritz C. Eilber and Hong Wu. PTEN dosage is
essential for neurofibroma development and malignant transformation.
PNAS November 17, 2009 vol.106 no.46:19479-19484.
9. David J. Mulholland, Li Xin, Ashkan Morim, Devon Lawson, Owen Witte,
and Hong Wu Lin-Sca-1+CD49f high stem/progenitors are tumor-
initiating cells in the Pten-null prostate cancer model. Cancer Res.
2009 Nov 15;69(22):8555-62.
10. Caroline Gregorian, Jonathan Nakashima, Janel Le Belle, John Ohab,
Rachel Kim, Annie Liu, Kate Barzan Smith, Matthias Groszer, A. Denise Garcia
, Michael V. Sofroniew, S. Thomas Carmichael, Harley I. Kornblum, Xin Liu,
and Hong Wu Pten deletion in adult neural stem/progenitor cells
enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):
1874-86.
11. Bahram Valamehr, Steven J. Jonas, Julien Polleux, Rong Qiao, Shuling
Guo, Eric H. Gschweng, Bangyan Stiles, Korey Kam, Tzy-Jiun M. Luo, Owen N.
Witte, Xin Liu, Bruce Dunn, and Hong Wu Hydrophobic surfaces for
enhanced differentiation of embryonic stem cell-derived embryoid bodies
8232;PNAS, 12 September 2008.
12. Wei Guo, Joseph L. Lasky, Chun-Ju Chang, SherlyMosessian, Xiaoman
Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe,
MarileilaVarella-Garcia & Hong Wu Multi-genetic events
collaboratively contribute to Pten-null leukaemia stem-cell formation .
8232; Nature 2008 May 22;453(7194):529-33.
13. Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON,
Liu X, Wu H NKX3.1 stabilizes p53, inhibits AKT activation, and
blocks prostate cancer initiation caused by PTEN loss. Cancer Cell.
2006 May;9(5):367-78.
14. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J,
Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively
regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
. PNAS. 2006 Jan 3;103(1):111-6
15. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y,
Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA,
Dor Y Pten constrains centroacinar cell expansion and malignant
transformation in the pancreas. Cancer Cell. 2005 Sep;8(3):185-95.
16. Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li
G, Roy-Burman P, Nelson PS, Liu X, Wu H. Prostate-specific deletion
of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
. Cancer Cell. 2003 Sep;4(3):209-21.
17. Tsai PT, Lee RA, Wu H. BMP4 acts upstream of FGF in modulating
thymic stroma and regulating thymopoiesis. Blood. 2003 Aug 14
18. Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD,
Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H. PTEN tumor
suppressor regulates p53 protein levels and activity through phosphatase-
dependent and -independent mechanisms. Cancer Cell. 2003 Feb;3(2):117
-30.
19. Anzelon AN, Wu H, Rickert RC. Pten inactivation alters
peripheral B lymphocyte fate and reconstitutes CD19 function. Nat
Immunol. 2003 Mar;4(3):287-94.
20. Jegalian AG, Acurio A, Dranoff G, Wu H. Erythropoietin
receptor haploinsufficiency and in vivo interplay with granulocyte-
macrophage colony-stimulating factor and interleukin 3. Blood. 2002
Apr 1;99(7):2603-5.
21. Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack
JA, Kornblum HI, Liu X, Wu H. Negative regulation of neural stem/
progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
8232;Science. 2001 Dec 7;294(5549):2186-9
22. Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H. Erythropoietin
(Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001
Sep 1;98(5):1408-15.
23. Liliental,J., Lesche, R., Moon, S-Y., Mamillapalli, R., Gavrilova, N.
, Sun, H., Zheng, Y., and Wu, H. Genetic Deletion of the Pten Tumor
Suppressor Gene Promotes Cell Motility by Activation of Rac1 and Cdc42
GTPases. Curr Biol. 2000 Apr 6;10(7):401-4.
24. Sun, H., Lesche, R., Li, DM., Liliental, J., Zhang, H., Gao, J.,
Garvarina, N., Mueller, B., Liu, X. and Wu, H. PTEN Modulates Cell
Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling
Pathway. PNAS. 1999 May 25;96(11):6199-204.
