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请问一般ChIPseq应该有多少peaks?
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请问一般ChIPseq应该有多少peaks?# Biology - 生物学
c*1
1
I am helping the hiring manager find a right candidate to fill the senior
manager position in the team. Please see below for the detailed job
description. feel free to send me your resume if you believe you are a good
fit. The position is in Arlington, VA.
Detailed Description

Responsibilities include:
· Manage and oversee monthly production of Balance sheet forecast
inclusive of activity (purchases, dispositions, pay-downs, etc.), size,
composition, and net free funds against most recent forward curve.
· Prepare and support spread forecast reporting by Enterprise,
Segment, and legal entity inclusive of spread contribution across all
investment and funding classifications.
· Manage Treasury investments / Apply IRR & NPV capital budgeting
techniques to determine optimal investment decisions as relates to balance
sheet. Ad hoc Loan and Security, and wholesale borrowing portfolio
performance analysis.
· Prepare and support actual regulatory capital performance and
support ongoing forecast. Manage the forecast of Bank ratios under both OCC
/Fed as well as Basel III guidelines to ensure within required limits once
changes implemented (in coordination with regulatory reporting and tax).
· Develop and lead simplified simulation modeling for projection of
both Tier 1 and Risk Based capital within the bank, as well as related
holding company capital ratios, inclusive of alternative rate scenarios,
balance sheet size (leverage versus deleverage), and alternative scenarios
that utilize impact factors such as capital down-streams, bank after tax
earnings projections, deferred tax asset impacts, OCI, loan losses, and
reserve allowances (ALLL).
· Lead Monthly Estimate process to provide changes to forecasts
highlighting the major deviations and causes for management attention for E*
Trade Bank.
· Manage and maintain Distributed Planning Hyperion application.
Maintain and manage dimension structure - chart of accounts used in forecast
process, asset / liability classifications and rollups, other dimensions
defining how data needs to be reported, viewed, or analyzed.
· Develop presentations of financial analysis to be delivered to
the executive level
· Support Asset Liability Committee standardized reporting and ad
hoc analysis as requested by senior management
· Candidate focus will initially be on supporting the balance sheet
forecasting process inclusive of yield table output and capital
· Preparation of presentations will be required. The candidate will
be expected to take an immediate leadership role requiring in-depth
financial analysis around specific what-if capital scenarios.

Job Requirements

Basic Qualifications:
· 7-9 years of financial planning and analysis and/or accounting
experience
· Solid technical and analytical skills in finance, general
accounting, budgeting, financial analysis. An understanding of the basic
business disciplines in order to develop, analyze and interpret financial
data.
· Previous experience with Oracle/Hyperion financial applications.
Strong interpersonal and communication skills to work effectively with
various functional groups.
· Bank Treasury Finance experience strongly preferred.
· Bachelor degree in Finance, Accounting, Economics or other
business related field.
· MBA preferred.
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j*g
2
当然取决于细胞系和target蛋白。
但是泛泛而言,数量级一般是多少?
比如组蛋白修饰,十万?一万?
转录因子,一万?两千?五百?
谢谢!
avatar
r*r
3
master regulator一般在一两万以上。组蛋白修饰比这个多一些。
一般的转录因子会少些,几千。

【在 j*********g 的大作中提到】
: 当然取决于细胞系和target蛋白。
: 但是泛泛而言,数量级一般是多少?
: 比如组蛋白修饰,十万?一万?
: 转录因子,一万?两千?五百?
: 谢谢!

avatar
e*6
4
请教一下peak是什么意思?

【在 j*********g 的大作中提到】
: 当然取决于细胞系和target蛋白。
: 但是泛泛而言,数量级一般是多少?
: 比如组蛋白修饰,十万?一万?
: 转录因子,一万?两千?五百?
: 谢谢!

avatar
a*r
5
protein binding region on DNA

【在 e*********6 的大作中提到】
: 请教一下peak是什么意思?
avatar
j*g
6
组蛋白修饰多少?十万?
[在 repeatmasker (repeatmarker) 的大作中提到:]
:master regulator一般在一两万以上。组蛋白修饰比这个多一些。
:一般的转录因子会少些,几千。
avatar
e*6
7
这是不是可以理解为测序到的reads的数量?

【在 a******r 的大作中提到】
: protein binding region on DNA
avatar
f*e
8
Reads数量你钱多你就狂测,到一定depth后再多也不会改变peak数量,可能peak会好
看一点吧


: 这是不是可以理解为测序到的reads的数量?



【在 e*********6 的大作中提到】
: 这是不是可以理解为测序到的reads的数量?
avatar
e*6
9
是不是region的范围大一些?

【在 f*******e 的大作中提到】
: Reads数量你钱多你就狂测,到一定depth后再多也不会改变peak数量,可能peak会好
: 看一点吧
:
:
: 这是不是可以理解为测序到的reads的数量?
:

avatar
j*g
10
当然取决于细胞系和target蛋白。
但是泛泛而言,数量级一般是多少?
比如组蛋白修饰,十万?一万?
转录因子,一万?两千?五百?
谢谢!
avatar
r*r
11
master regulator一般在一两万以上。组蛋白修饰比这个多一些。
一般的转录因子会少些,几千。

【在 j*********g 的大作中提到】
: 当然取决于细胞系和target蛋白。
: 但是泛泛而言,数量级一般是多少?
: 比如组蛋白修饰,十万?一万?
: 转录因子,一万?两千?五百?
: 谢谢!

avatar
e*6
12
请教一下peak是什么意思?

【在 j*********g 的大作中提到】
: 当然取决于细胞系和target蛋白。
: 但是泛泛而言,数量级一般是多少?
: 比如组蛋白修饰,十万?一万?
: 转录因子,一万?两千?五百?
: 谢谢!

avatar
a*r
13
protein binding region on DNA

【在 e*********6 的大作中提到】
: 请教一下peak是什么意思?
avatar
j*g
14
组蛋白修饰多少?十万?
[在 repeatmasker (repeatmarker) 的大作中提到:]
:master regulator一般在一两万以上。组蛋白修饰比这个多一些。
:一般的转录因子会少些,几千。
avatar
e*6
15
这是不是可以理解为测序到的reads的数量?

【在 a******r 的大作中提到】
: protein binding region on DNA
avatar
f*e
16
Reads数量你钱多你就狂测,到一定depth后再多也不会改变peak数量,可能peak会好
看一点吧


: 这是不是可以理解为测序到的reads的数量?



【在 e*********6 的大作中提到】
: 这是不是可以理解为测序到的reads的数量?
avatar
e*6
17
是不是region的范围大一些?

【在 f*******e 的大作中提到】
: Reads数量你钱多你就狂测,到一定depth后再多也不会改变peak数量,可能peak会好
: 看一点吧
:
:
: 这是不是可以理解为测序到的reads的数量?
:

avatar
f*e
18
region?你指interval?peak width?
到一定深度后不会有太多改变的,可以说越多越好,但是enough is enough,没必要浪
费钱,还不如多几个重复


: 是不是region的范围大一些?



【在 e*********6 的大作中提到】
: 是不是region的范围大一些?
avatar
B*U
19
不觉得有泛泛的数量级
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431496/figure/F3/
QC的话follow这篇文章也是不错的

【在 j*********g 的大作中提到】
: 当然取决于细胞系和target蛋白。
: 但是泛泛而言,数量级一般是多少?
: 比如组蛋白修饰,十万?一万?
: 转录因子,一万?两千?五百?
: 谢谢!

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