ADAGIO研究纳入1176名未经治疗的PD患者,随机分为早期治疗组(接受剂量为每天1mg或2mg的雷沙吉兰治疗72周)和延迟治疗组(先安慰剂治疗36周,再每天使用1mg或2mg雷沙吉兰治疗36周)。 结果发现,1mg/d雷沙吉兰早期治疗组明显优于延迟治疗组,而2mg/d雷沙吉兰可能不具有疾病修饰作用。但该研究随访3年的结果提示,早期治疗与延迟治疗的UPDRS总分无显著性差异,因此雷沙吉兰的疾病修饰作用仍不能确定。 PD修饰疗法的现状如何?哪些药物可以用于PD的DMT?PD的DMT在未来将迎来哪些挑战?机遇又在哪里? 扫描下方二维码,搜索复旦大学附属华山医院神经内科王坚教授《帕金森病的疾病修饰疗法》精彩讲座,为您呈现 现在下载医学界医生站APP,可免认证48小时观看所有课程, 赶紧来试看! 参考文献:[1] Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. 1993 Jan 21;328(3):176-83. doi: 10.1056/NEJM199301213280305. PMID: 8417384.[2] Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, Olanow CW, Tanner C, Marek K; Parkinson Study Group. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 9;351(24):2498-508. doi: 10.1056/NEJMoa033447. PMID: 15590952.[3]Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston W, Melamed E, Poewe W, Stocchi F, Tolosa E; ADAGIO Study Investigators. 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