j*2
2 楼
总结一下联系方式
然后大家联名发信，希望他们能像饶毅一下，对Nature发声。
然后大家联名发信，希望他们能像饶毅一下，对Nature发声。
l*1
3 楼
这个 有点过bottom line 了吧 ?
自愿自发 的 非暴力不合作运动
参看 甘地
【在 j*******2 的大作中提到】
: 总结一下联系方式
: 然后大家联名发信，希望他们能像饶毅一下，对Nature发声。
自愿自发 的 非暴力不合作运动
参看 甘地
【在 j*******2 的大作中提到】
: 总结一下联系方式
: 然后大家联名发信，希望他们能像饶毅一下，对Nature发声。
j*2
4 楼
不是逼迫，就是让他们知道这回事。
【在 l**********1 的大作中提到】
: 这个 有点过bottom line 了吧 ?
: 自愿自发 的 非暴力不合作运动
: 参看 甘地
【在 l**********1 的大作中提到】
: 这个 有点过bottom line 了吧 ?
: 自愿自发 的 非暴力不合作运动
: 参看 甘地
l*1
5 楼
BGI or others just try
NGS with both blood samples Ye Shiwen and Katie Ledecky
plus below six athletes total 8 athletes
performance profiling”方法，将所有国际上
有名的现役游泳运动员的比赛成绩，进行profiling分析，发现最高分排名（也就是最
“anomalous”的排名）是：
1. Elizabeth Beisel
2. Michael Phelps
3. Rebecca Adlington
4. Ian Thorpe
5. Stephanie Rice
6. Allison Schmitt
while can find proof of her EPOR mutation which is identical to Finnish
cross-country skier Eero Mäntyranta
and also is different to former matchs any DNA samples Genetic Data then
may belong to Gene Doping with high probability.
if complted same to all former matchs any DNA samples Genetic Data
then s/he is just Finnish cross-country
skier Eero Mäntyranta next generation whom is natural selected not Gene
Doping.
Of course, it will be accpeted for publihsing in Science magazine as
Research Article.
Pls refer:
一些罕见的变异会将超级运动员和世界级的运动员区分开来。例如，芬兰的越野滑雪选
手、七枚奥运会奖牌得主埃罗·门蒂兰塔的红细胞生成素受体（EPOR）发生的一种基因
突变让他能比正常人多产生25%的红细胞，这就让他的血液中携带着比普通人更多的氧
气。
这就解释了有的人为什么不用兴奋剂也能有突出的表现。既然Nature是科学杂志，就应
该从科学的角度来解释叶诗文的问题，而不应该用不可知论来解释。
http://www.bioon.com/trends/news/527408.shtml
and Nature
Performance enhancement: Superhuman athletes
Enhancements such as doping are illegal in sport — but if all restrictions
were lifted, science could push human performance to new extremes.
by Helen Thompson
18 July 2012
Code breaking
Gene doping — enhancing performance by adding or modifying genes — has
been the subject of locker-room gossip for the past ten years. There are
plenty of natural mutations for which to wish. The Finnish cross-country
skier Eero Mäntyranta, who won three gold medals in the early 1960s,
had a mutation that made his body’s EPO receptors more efficient. In 2004,
a toddler made headlines for having a mutation that disabled myostatin,
giving him the physique of a petite body builder. And the gene that encodes
angotensin-converting enzyme, which has been hailed as the gene for physical
performance, has one variation known to boost endurance by increasing
oxygen delivery capacity and capillary density, and another that is
associated with muscle growth and strength6, 7.
GARY NEILL
Advances in gene therapy could one day make it possible for any athlete to
enhance their DNA. For example, in experiments aimed at treating muscular
dystrophy in the elderly, a group led by physiologist Lee Sweeney of the
University of Pennsylvania in Philadelphia introduced a gene to cause over-
expression of IGF1 in mice. The treatment boosted muscle strength of young
adult mice by 14%, earning the rodents the nickname ‘mighty mice’8.
Other researchers are turning genes on and off with drugs. In 2008, Ronald
Evans and his colleagues at the Salk Institute for Biological Studies in La
Jolla, California, worked with GW1516, a drug that activates a gene that
increases the ratio of ‘slow-twitch’ to ‘fast-twitch’ fibres in muscle.
As the names suggest, slow-twitch fibres contract more slowly than fast-
twitch, but they are more efficient at aerobic activity. Evans and his team
found9 that in mice, GW1516 combined with exercise increased the rodents’
endurance by 70%.
However, both Evans and Sweeney are sceptical about how useful athletes will
find such therapies. “In humans, I expect the same general relationship —
the under-exercised will be the ones who will have the most benefit from
exercise mimetics,” says Evans. “My view is that endurance athletes are
physically advantaged and will have the least benefits.”
Gene therapy has its share of health risks, including potentially severe
immune reactions to the viruses used to ferry genetic material into cells.
The results may also be hard to control. “If you’re going to turn a gene
for something like EPO on, you better be able to turn it off,” warns Catlin
. Gene doping, he says, “is not a good idea, but I wouldn’t be surprised
if someone’s out there trying it”.
//www.nature.com/news/performance-enhancement-superhuman-athletes-1.11029
---
同主题阅读：反击Nature的最佳策略！
[版面:生物学][首篇作者：Carwash] , 2012年08月03日15:29:34
发信人: Carwash (for+free), 信区: Biology
标 题: 反击Nature的最佳策略！
发信站: BBS 未名空间站 (Fri Aug 3 15:46:08 2012, 美东)
我写了一篇文章，使用了这个作者的“performance profiling”方法，将所有国际上
有名的现役游泳运动员的比赛成绩，进行profiling分析，发现最高分排名（也就是最
“anomalous”的排名）是：
1. Elizabeth Beisel
2. Michael Phelps
3. Rebecca Adlington
4. Ian Thorpe
5. Stephanie Rice
6. Allison Schmitt
7. Ye Shiwen
结论：
这个“performance profiling”方法，检测的灵敏度很低，实际上还不如现在的drug
tests有效。而且，false positive rate太高，容易导致错误判断，冤枉优秀的运动员。
所以，“performance profiling”不适用于运动员的药物检测。
我准备把这篇文章，发到Nature上去，不知道会不会被接受。
http://www.mitbbs.com/article_t/Biology/31709693.html
------
NB: From 2032 Summer and Winter Olympic Games may be over
if human can not control Gene doping or Stem Cell Doping techniques
withth reseanable reasonable tools and cost
Here maens that every athlete should produce her/his born that time DNA
samples or DNA chips data for checking the possbe manipulated Gene or Stem
Cell by human and not from natural selections.
【在 j*******2 的大作中提到】
: 不是逼迫，就是让他们知道这回事。
NGS with both blood samples Ye Shiwen and Katie Ledecky
plus below six athletes total 8 athletes
performance profiling”方法，将所有国际上
有名的现役游泳运动员的比赛成绩，进行profiling分析，发现最高分排名（也就是最
“anomalous”的排名）是：
1. Elizabeth Beisel
2. Michael Phelps
3. Rebecca Adlington
4. Ian Thorpe
5. Stephanie Rice
6. Allison Schmitt
while can find proof of her EPOR mutation which is identical to Finnish
cross-country skier Eero Mäntyranta
and also is different to former matchs any DNA samples Genetic Data then
may belong to Gene Doping with high probability.
if complted same to all former matchs any DNA samples Genetic Data
then s/he is just Finnish cross-country
skier Eero Mäntyranta next generation whom is natural selected not Gene
Doping.
Of course, it will be accpeted for publihsing in Science magazine as
Research Article.
Pls refer:
一些罕见的变异会将超级运动员和世界级的运动员区分开来。例如，芬兰的越野滑雪选
手、七枚奥运会奖牌得主埃罗·门蒂兰塔的红细胞生成素受体（EPOR）发生的一种基因
突变让他能比正常人多产生25%的红细胞，这就让他的血液中携带着比普通人更多的氧
气。
这就解释了有的人为什么不用兴奋剂也能有突出的表现。既然Nature是科学杂志，就应
该从科学的角度来解释叶诗文的问题，而不应该用不可知论来解释。
http://www.bioon.com/trends/news/527408.shtml
and Nature
Performance enhancement: Superhuman athletes
Enhancements such as doping are illegal in sport — but if all restrictions
were lifted, science could push human performance to new extremes.
by Helen Thompson
18 July 2012
Code breaking
Gene doping — enhancing performance by adding or modifying genes — has
been the subject of locker-room gossip for the past ten years. There are
plenty of natural mutations for which to wish. The Finnish cross-country
skier Eero Mäntyranta, who won three gold medals in the early 1960s,
had a mutation that made his body’s EPO receptors more efficient. In 2004,
a toddler made headlines for having a mutation that disabled myostatin,
giving him the physique of a petite body builder. And the gene that encodes
angotensin-converting enzyme, which has been hailed as the gene for physical
performance, has one variation known to boost endurance by increasing
oxygen delivery capacity and capillary density, and another that is
associated with muscle growth and strength6, 7.
GARY NEILL
Advances in gene therapy could one day make it possible for any athlete to
enhance their DNA. For example, in experiments aimed at treating muscular
dystrophy in the elderly, a group led by physiologist Lee Sweeney of the
University of Pennsylvania in Philadelphia introduced a gene to cause over-
expression of IGF1 in mice. The treatment boosted muscle strength of young
adult mice by 14%, earning the rodents the nickname ‘mighty mice’8.
Other researchers are turning genes on and off with drugs. In 2008, Ronald
Evans and his colleagues at the Salk Institute for Biological Studies in La
Jolla, California, worked with GW1516, a drug that activates a gene that
increases the ratio of ‘slow-twitch’ to ‘fast-twitch’ fibres in muscle.
As the names suggest, slow-twitch fibres contract more slowly than fast-
twitch, but they are more efficient at aerobic activity. Evans and his team
found9 that in mice, GW1516 combined with exercise increased the rodents’
endurance by 70%.
However, both Evans and Sweeney are sceptical about how useful athletes will
find such therapies. “In humans, I expect the same general relationship —
the under-exercised will be the ones who will have the most benefit from
exercise mimetics,” says Evans. “My view is that endurance athletes are
physically advantaged and will have the least benefits.”
Gene therapy has its share of health risks, including potentially severe
immune reactions to the viruses used to ferry genetic material into cells.
The results may also be hard to control. “If you’re going to turn a gene
for something like EPO on, you better be able to turn it off,” warns Catlin
. Gene doping, he says, “is not a good idea, but I wouldn’t be surprised
if someone’s out there trying it”.
//www.nature.com/news/performance-enhancement-superhuman-athletes-1.11029
---
同主题阅读：反击Nature的最佳策略！
[版面:生物学][首篇作者：Carwash] , 2012年08月03日15:29:34
发信人: Carwash (for+free), 信区: Biology
标 题: 反击Nature的最佳策略！
发信站: BBS 未名空间站 (Fri Aug 3 15:46:08 2012, 美东)
我写了一篇文章，使用了这个作者的“performance profiling”方法，将所有国际上
有名的现役游泳运动员的比赛成绩，进行profiling分析，发现最高分排名（也就是最
“anomalous”的排名）是：
1. Elizabeth Beisel
2. Michael Phelps
3. Rebecca Adlington
4. Ian Thorpe
5. Stephanie Rice
6. Allison Schmitt
7. Ye Shiwen
结论：
这个“performance profiling”方法，检测的灵敏度很低，实际上还不如现在的drug
tests有效。而且，false positive rate太高，容易导致错误判断，冤枉优秀的运动员。
所以，“performance profiling”不适用于运动员的药物检测。
我准备把这篇文章，发到Nature上去，不知道会不会被接受。
http://www.mitbbs.com/article_t/Biology/31709693.html
------
NB: From 2032 Summer and Winter Olympic Games may be over
if human can not control Gene doping or Stem Cell Doping techniques
withth reseanable reasonable tools and cost
Here maens that every athlete should produce her/his born that time DNA
samples or DNA chips data for checking the possbe manipulated Gene or Stem
Cell by human and not from natural selections.
【在 j*******2 的大作中提到】
: 不是逼迫，就是让他们知道这回事。
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